Metap2 Gene Summary [Mouse]
Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Predicted to be involved in N-terminal protein amino acid modification; peptidyl-methionine modification; and protein processing. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in brain; cerebral cortex ventricular layer; cortical plate; and telencephalon. Orthologous to human METAP2 (methionyl aminopeptidase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Metap2 |
| Official Name | methionine aminopeptidase 2 [Source:MGI Symbol;Acc:MGI:1929701] |
| Ensembl ID | ENSMUSG00000036112 |
| Bio databases IDs | |
| Aliases | methionine aminopeptidase 2 |
| Synonyms | 4930584B20RIK, A930035J23RIK, Amp2, AU014659, MAP2, METHIONINE AMINOPEPTIDASE2, methionyl aminopeptidase 2, METPEP, MNPEP, p67, p67eIF2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Metap2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metallopeptidase family M24
- metalloexopeptidase
- methionine aminopeptidase, type II
- peptidase
- aminopeptidase
- protein binding
- APP_MetAP
- glycosylation site
Pathways
Biological processes and signaling networks where the Metap2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- acute myeloid leukemia
- psoriasis
- gastrulation failure
- nonmuscle invasive bladder cancer
- aortic valve calcification
role in cell
- formation
- proliferation
- growth
- contact growth inhibition
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Metap2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- N-terminal protein amino acid modification
- protein processing
- peptidyl-methionine modification
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- methionyl aminopeptidase activity
- protein binding
- RNA binding
- metal ion binding
- metalloexopeptidase activity
- metalloaminopeptidase activity
- aminopeptidase activity