Med23 Gene Summary [Mouse]
Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within positive regulation of T cell extravasation and positive regulation of gene expression. Part of mediator complex. Is expressed in several structures, including genitourinary system; tibialis anterior; and tongue. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 18. Orthologous to human MED23 (mediator complex subunit 23). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Med23 |
| Official Name | mediator complex subunit 23 [Source:MGI Symbol;Acc:MGI:1917458] |
| Ensembl ID | ENSMUSG00000019984 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 23 |
| Synonyms | 3000002A17Rik, ARC130, CRSP130, CRSP133, CRSP3, DRIP130, ESTM7, KIAA1216, Med130, mediator complex subunit 23, mKIAA1216, MRT18, sno, snouty, SUR-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Med23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- ubiquitin protein ligase activity
- protein binding
- Mediator complex subunit 23
Pathways
Biological processes and signaling networks where the Med23 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- autosomal recessive mental retardation type 18
- non-insulin-dependent diabetes mellitus
- autosomal recessive mental retardation type 18 with epilepsy
- mental retardation
- neurodevelopmental disorder
- growth failure
- hyperargininemia
- autosomal recessive mental retardation type 18 without epilepsy
- hereditary disorder
regulated by
- beta-estradiol
- tretinoin
- wrenchnolol
- geldanamycin
- interferon alpha
- MED24
- tetrachlorodibenzodioxin
role in cell
- extravasation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Med23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- positive regulation of gene expression
- positive regulation of T cell extravasation
- regulation of transcription, DNA-dependent
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- core mediator complex
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity