Acta1 Gene Summary [Mouse]
Predicted to enable ATP binding activity and hydrolase activity. Involved in skeletal muscle fiber development. Predicted to be located in several cellular components, including filopodium; lamellipodium; and sarcomere. Predicted to be part of protein-containing complex. Predicted to be active in actin filament; stress fiber; and striated muscle thin filament. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and limb. Used to study nemaline myopathy 3. Human ortholog(s) of this gene implicated in congenital myopathy 2B; congenital myopathy 2C; and nemaline myopathy 3. Orthologous to human ACTA1 (actin alpha 1, skeletal muscle). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acta1 |
| Official Name | actin, alpha 1, skeletal muscle [Source:MGI Symbol;Acc:MGI:87902] |
| Ensembl ID | ENSMUSG00000031972 |
| Bio databases IDs | |
| Aliases | actin, alpha 1, skeletal muscle |
| Synonyms | ACTA, Acta-2, actin alpha 1, skeletal muscle, actin, alpha 1, skeletal muscle, actin α 1, skeletal muscle, actin, α 1, skeletal muscle, Acts, Actsk-1, alpha1 ACTIN, alpha-SKA, alpha SKELETAL ACTIN, ASMA, CFTD, CFTD1, CFTDM, CMYO2A, CMYO2B, CMYO2C, CMYP2A, CMYP2B, CMYP2C, Fetal isoform of skeletal alpha-actin, Fetal isoform of skeletal α-actin, foetal isoform of skeletal alpha-actin, foetal isoform of skeletal α-actin, G-actin, MPFD, NEM1, NEM2, NEM3, SHPM, skACT, SKELETAL alpha-ACTIN, SKELETAL MUSCLE ACTIN, SKELETAL α-ACTIN, α-SKA, α SKELETAL ACTIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acta1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin binding
- structural constituent of cytoskeleton
- Actin
- ADP binding
- ATP binding
- protein binding
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Acta1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agranulocyte Adhesion and Diapedesis
- Calcium Signaling
- Caveolar-mediated Endocytosis Signaling
- Cellular Effects of Sildenafil (Viagra)
- Clathrin-mediated Endocytosis Signaling
- Death Receptor Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Gap Junction Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- ILK Signaling
- Leukocyte Extravasation Signaling
- Mechanisms of Viral Exit from Host Cells
- MSP-RON Signaling Pathway
- NRF2-mediated Oxidative Stress Response
- Regulation of Actin-based Motility by Rho
- Remodeling of Epithelial Adherens Junctions
- RhoA Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- TEC Kinase Signaling
- Tight Junction Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- nemaline myopathy 3
- nemaline myopathy
- autosomal dominant severe infantile congenital myopathy 2c
- prostate cancer
- alpha-actinopathy
- hereditary disorder
- myopathy
- scoliosis
- congenital myopathy with fiber type disproportion
role in cell
- proliferation
- migration
- nucleation
- abnormal morphology
- assembly
- diameter
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- actin cytoskeleton
- Nucleus
- actin filaments
- sarcomere
- cytosol
- Golgi membrane
- myofibrils
- microfilaments
- actin stress fibers
- filopodia
- cell membrane leading edge
- perikaryon
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acta1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal muscle fiber development
- muscle contraction
- positive regulation of gene expression
- skeletal muscle thin filament assembly
- mesenchyme migration
- response to steroid hormone stimulus
- cellular response to organic nitrogen
- skeletal muscle fiber adaptation
- response to mechanical stimulus
Cellular Component
Where in the cell the gene product is active
- actin filament
- striated muscle thin filament
- extracellular space
- extracellular vesicular exosome
- stress fiber
- cell body
- blood microparticle
- actin cytoskeleton
- cytosol
- filopodium
- sarcomere
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- myosin binding
- structural constituent of cytoskeleton
- ADP binding
- hydrolase activity