E2f6 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within G1/S transition of mitotic cell cycle and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of MLL1 complex and RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Orthologous to human E2F6 (E2F transcription factor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | E2f6 |
| Official Name | E2F transcription factor 6 [Source:MGI Symbol;Acc:MGI:1354159] |
| Ensembl ID | ENSMUSG00000057469 |
| Bio databases IDs | |
| Aliases | E2F transcription factor 6 |
| Synonyms | AI462434, E2F6a, E2F6b, E2F transcription factor 6, EMA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse E2f6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- DNA binding domain
- nucleic acid binding
- leucine zipper domain
- protein binding
- Dimerization domain of E2F transcription factors
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- double-stranded DNA binding
- E2F/DP family winged-helix DNA-binding domain
- transcription factor activity
- marked box
Pathways
Biological processes and signaling networks where the E2f6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Bladder Cancer Signaling
- Breast Cancer Regulation by Stathmin1
- Cell Cycle Regulation by BTG Family Proteins
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- DNA Methylation and Transcriptional Repression Signaling
- Estrogen-mediated S-phase Entry
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of BRCA1 in DNA Damage Response
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- oligozoospermia
- heart failure
- growth failure
- anemia
- hyperplasia
- hypoplasia
- ataxia
role in cell
- proliferation
- apoptosis
- number
- expression in
- transactivation in
- accumulation
- cell cycle progression
- S phase
- transcription in
- replicative senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse E2f6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- MLL1 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity