Klf12 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human KLF12 (KLF transcription factor 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klf12 |
| Official Name | Kruppel-like factor 12 [Source:MGI Symbol;Acc:MGI:1333796] |
| Ensembl ID | ENSMUSG00000072294 |
| Bio databases IDs | |
| Aliases | Kruppel-like factor 12 |
| Synonyms | 2700063E05RIK, AP2REP, B130052C06RIK, D530033K05RIK, HSPC122, KLF transcription factor 12, Kruppel-like transcription factor 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klf12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- CtBP binding domain
- transcription regulator
- N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- Zinc-finger double domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- prostate cancer
- major depression
- pulmonary emphysema
- atrial fibrillation
- bronchopulmonary dysplasia
- human papilloma virus infection
- alcoholism
- systemic lupus erythematosus
role in cell
- expression in
- apoptosis
- binding in
- differentiation
- proliferation
- S phase
- growth
- transactivation in
- development
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klf12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity