Tm7sf2 Gene Summary [Mouse]
Enables Delta14-sterol reductase activity. Involved in cholesterol biosynthetic process. Located in organelle membrane. Is expressed in several structures, including adrenal gland; alimentary system; eye; liver; and nervous system. Orthologous to human TM7SF2 (transmembrane 7 superfamily member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tm7sf2 |
| Official Name | transmembrane 7 superfamily member 2 [Source:MGI Symbol;Acc:MGI:1920416] |
| Ensembl ID | ENSMUSG00000024799 |
| Bio databases IDs | |
| Aliases | transmembrane 7 superfamily member 2 |
| Synonyms | 3110041O18Rik, ANG1, Av156900, C14SR, Dhcr14, DHCR14A, NET47, transmembrane 7 superfamily member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tm7sf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- D14-sterol reductase
- NADP binding
- enzyme
- protein binding
- delta14-sterol reductase
- Isoprenylcysteine carboxyl methyltransferase (ICMT) family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tm7sf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cholesterol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear inner membrane
- intracellular membrane-bounded organelle
- endoplasmic reticulum
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- NADP binding
- protein binding
- delta14-sterol reductase activity