Mapk7 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity. Involved in protein phosphorylation. Acts upstream of or within several processes, including negative regulation of calcineurin-NFAT signaling cascade; peptidyl-serine phosphorylation; and regulation of angiogenesis. Located in cytosol and nucleus. Is expressed in several structures, including cardiovascular system; early conceptus; gonad; nervous system; and salivary gland. Orthologous to human MAPK7 (mitogen-activated protein kinase 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Mapk7 |
| Official Name | mitogen-activated protein kinase 7 [Source:MGI Symbol;Acc:MGI:1346347] |
| Ensembl ID | ENSMUSG00000001034 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase 7 |
| Synonyms | b2b2346Clo, BMK-1, ERK4, ERK-5, Erk5-T, ERK7, FRK, LOC100912585, mitogen-activated protein kinase 7, PRKM7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mapk7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- subdomain of kinase domain
- protein kinase binding
- catalytic domain
- ATP binding
- transcription activation domain
- protein binding
- Protein kinase domain
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- MAP kinase
- alcohol group acceptor phosphotransferase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Mapk7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Apelin Adipocyte Signaling Pathway
- Apelin Cardiomyocyte Signaling Pathway
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Cholecystokinin/Gastrin-mediated Signaling
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- ERK5 Signaling
- G-Protein Coupled Receptor Signaling
- Gap Junction Signaling
- GNRH Signaling
- Gα12/13 Signaling
- Neuroinflammation Signaling Pathway
- NGF Signaling
- NRF2-mediated Oxidative Stress Response
- Nur77 Signaling in T Lymphocytes
- Opioid Signaling Pathway
- Phagosome Formation
- Role of Tissue Factor in Cancer
- Sirtuin Signaling Pathway
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- metastasis
- impaired glucose tolerance
- Alzheimer disease
- kyphosis
- bleeding
- hypoplasia
- susceptibility to idiopathic scoliosis type 1
- edema
role in cell
- proliferation
- expression in
- apoptosis
- cell death
- production in
- growth
- activation in
- transcription in
- phosphorylation in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mapk7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcineurin-NFAT signaling cascade
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- negative regulation of response to cytokine stimulus
- negative regulation of smooth muscle cell apoptotic process
- signal transduction
- negative regulation of inflammatory response
- regulation of angiogenesis
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- cellular response to transforming growth factor beta stimulus
- MAPK cascade
- positive regulation of protein metabolic process
- cellular response to growth factor stimulus
- negative regulation of calcineurin-NFAT signaling cascade
- cell differentiation
- negative regulation of heterotypic cell-cell adhesion
- cellular response to laminar fluid shear stress
- negative regulation of endothelial cell apoptotic process
- cellular response to hydrogen peroxide
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- enzyme inhibitor activity
- MAP kinase activity
- protein serine/threonine kinase activity
- mitogen-activated protein kinase binding