Herc6 Gene Summary [Mouse]
Predicted to enable cyclin binding activity and ubiquitin protein ligase activity. Acts upstream of or within hematopoietic progenitor cell differentiation and response to bacterium. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in liver. Orthologous to human HERC6 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Herc6 |
| Official Name | hect domain and RLD 6 [Source:MGI Symbol;Acc:MGI:1914388] |
| Ensembl ID | ENSMUSG00000029798 |
| Bio databases IDs | |
| Aliases | hect domain and RLD 6 |
| Synonyms | 1700121D12Rik, 2510038N07Rik, 4930427L17Rik, CEB1, FLJ20637, HECT and RLD domain containing E3 ubiquitin protein ligase family member 6, hect domain and RLD 6, Herc5, LOC101929118 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Herc6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of chromosome condensation (RCC1) repeat
- HECTc
- ubiquitin protein ligase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- enzyme
- cyclin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- systemic lupus erythematosus
- psoriasis
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- dermatomyositis
- diabetes mellitus
- carbon tetrachloride-induced liver fibrosis
role in cell
- expression in
- production in
- activation in
- differentiation
- ubiquitination in
- degradation in
- isgylation in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Herc6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to bacterium
- hemopoietic progenitor cell differentiation
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleoplasm