Fus Gene Summary [Mouse]
Enables mRNA 3'-UTR binding activity. Acts upstream of or within RNA splicing. Located in cytoplasm and nucleus. Is active in several cellular components, including GABA-ergic synapse; postsynaptic cytosol; and presynaptic cytosol. Is expressed in several structures, including branchial arch; central nervous system; eye; genitourinary system; and tooth. Used to study amyotrophic lateral sclerosis type 6. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Orthologous to human FUS (FUS RNA binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fus |
| Official Name | fused in sarcoma [Source:MGI Symbol;Acc:MGI:1353633] |
| Ensembl ID | ENSMUSG00000030795 |
| Bio databases IDs | |
| Aliases | fused in sarcoma |
| Synonyms | ALS6, D430004D17Rik, D930039C12Rik, ETM4, FUS1, fused in sarcoma, Fusion, FUS RNA binding protein, HNRNPP2, Pigpen, POMP75, TLS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fus often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RGG domain
- RNA recognition motif (RRM) superfamily
- transcription regulator
- transcription co-activator
- low complexity domain
- RNA recognition motif
- RGG2 domain
- protein binding activity, bridging
- transcription activation domain
- chromatin binding
- estrogen receptor binding
- protein binding
- thyroid hormone receptor binding
- ionotropic glutamate receptor binding
- identical protein binding
- G/S Y G/S triplet repeat
- RNA binding
- myosin binding
- mRNA 3' UTR binding
- Zn-finger in Ran binding protein and others
- retinoid X receptor binding
- zinc finger domain
- prion-like domain
Pathways
Biological processes and signaling networks where the Fus gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- metastasis
- digestive system cancer
- abdominal cancer
- tumorigenesis
- motor dysfunction
- respiratory insufficiency
role in cell
- activation in
- interaction in
- binding in
- activity
- expression in
- formation
- formation in
- apoptosis
- proliferation
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- organelle
- Cytoplasm
- perinuclear region
- granules
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
- dendritic spines
- dendritic spine head
- synaptosomes
- synapse
- stress granule
- cellular protrusions
- chromatin
- perikaryon
- dendrites
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fus gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- positive regulation of transcription, DNA-dependent
- regulation of RNA splicing
- mRNA stabilization
- protein homooligomerization
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular non-membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- RNA binding
- transcription cofactor activity
- protein binding
- transcription coactivator activity
- metal ion binding
- chromatin binding
- mRNA 3'-UTR binding