Herc4 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Involved in spermatogenesis. Predicted to be located in cytosol and fibrillar center. Predicted to be active in cytoplasm. Orthologous to human HERC4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Herc4 |
| Official Name | hect domain and RLD 4 [Source:MGI Symbol;Acc:MGI:1914595] |
| Ensembl ID | ENSMUSG00000020064 |
| Bio databases IDs | |
| Aliases | hect domain and RLD 4 |
| Synonyms | 1700056O17RIK, 4921531D01Rik, 9530080M15Rik, HECT and RLD domain containing E3 ubiquitin protein ligase 4, hect domain and RLD 4, mKIAA1593 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Herc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of chromosome condensation (RCC1) repeat
- HECTc
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thoracic aortic aneurysm
- androgenic alopecia
- aortic valve calcification
role in cell
- expression in
- phosphorylation in
- K63 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Herc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- cell differentiation
- negative regulation of smoothened signaling pathway
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- fibrillar center