Ube2l3 Gene Summary [Mouse]
Enables ubiquitin conjugating enzyme activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; heart; immune system; lung; and reproductive system. Orthologous to several human genes including UBE2L3 (ubiquitin conjugating enzyme E2 L3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2l3 |
| Official Name | ubiquitin-conjugating enzyme E2L 3 [Source:MGI Symbol;Acc:MGI:109240] |
| Ensembl ID | ENSMUSG00000038965 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2L 3 |
| Synonyms | E2-F1, L-UBC, NEWGENE 1308361, Ubce7, UBCH7, UbcM4, UbcR7, ubiquitin-conjugating enzyme E2L 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube2l3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- transcription co-activator
- ubiquitin-protein transferase activity
- enzyme binding
- UBCc_UEV
- enzyme
- protein binding
- enzyme regulator activity
- enzyme activator activity
Pathways
Biological processes and signaling networks where the Ube2l3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- celiac disease
- ulcerative colitis
- Crohn disease
- systemic lupus erythematosus
- inflammatory bowel disease
- rheumatoid arthritis
- ankylosing spondylitis
- autoimmune disease
- idiopathic scoliosis
role in cell
- expression in
- production in
- cell death
- proliferation
- phagocytosis by
- degradation in
- phagocytosis
- cell survival
- downregulation in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- Cytoplasm
- presynaptic regions
- perinuclear region
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube2l3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- protein modification process
- protein K11-linked ubiquitination
- protein polyubiquitination
- regulation of transcription, DNA-dependent
- ubiquitin-dependent protein catabolic process
- cellular response to steroid hormone stimulus
- positive regulation of ubiquitin-protein ligase activity
- positive regulation of transcription, DNA-dependent
- cellular response to glucocorticoid stimulus
- positive regulation of protein ubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- ubiquitin-protein ligase activity
- ubiquitin protein ligase binding
- protein binding
- RNA binding
- ubiquitin-protein ligase activator activity
- transcription coactivator activity
- enzyme binding