Il21 Gene Summary [Mouse]
Enables cytokine receptor binding activity. Involved in cellular response to virus; lymphocyte activation involved in immune response; and positive regulation of immunoglobulin production. Acts upstream of or within positive regulation of cytokine production; positive regulation of natural killer cell differentiation; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in extracellular space. Is expressed in ductus deferens; epididymis; liver; and testis. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency 11; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il21 |
| Official Name | interleukin 21 [Source:MGI Symbol;Acc:MGI:1890474] |
| Ensembl ID | ENSMUSG00000027718 |
| Bio databases IDs | |
| Aliases | interleukin 21 |
| Synonyms | CVID11, interleukin 21, LOC547223, Za11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-2 receptor binding
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the Il21 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Erythropoietin Signaling
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-17 Signaling
- RAR Activation
- Role of Cytokines in Mediating Communication between Immune Cells
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- T Helper Cell Differentiation
- Th17 Activation Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- diabetes mellitus
- hyperplasia
- cancer
- experimental autoimmune encephalomyelitis
- metastasis
- gastric cancer
- sneeze
- fibrosis
role in cell
- phosphorylation in
- expression in
- activation in
- cellular infiltration by
- proliferation
- binding in
- apoptosis
- survival
- cell death
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- intracellular space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tyrosine phosphorylation of STAT protein
- signal transduction
- positive regulation of inflammatory response
- positive regulation of cell proliferation
- cell maturation
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of T cell proliferation
- positive regulation of natural killer cell mediated cytotoxicity
- germinal center B cell differentiation
- positive regulation of interferon-gamma production
- positive regulation of immunoglobulin production
- positive regulation of interleukin-17 production
- positive regulation of tissue remodeling
- defense response to virus
- positive regulation of B cell proliferation
- positive regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-2 receptor binding
- cytokine activity
- cytokine receptor binding