Atg4a Gene Summary [Mouse]
Predicted to enable cysteine-type endopeptidase activity and protein-phosphatidylethanolamide deconjugating activity. Predicted to be involved in macroautophagy; protein delipidation; and protein processing. Predicted to be active in cytoplasm. Is expressed in embryo. Orthologous to human ATG4A (autophagy related 4A cysteine peptidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atg4a |
| Official Name | autophagy related 4A, cysteine peptidase [Source:MGI Symbol;Acc:MGI:2147903] |
| Ensembl ID | ENSMUSG00000079418 |
| Bio databases IDs | |
| Aliases | autophagy related 4A, cysteine peptidase |
| Synonyms | Agt4a, AL672306.5, APG4A, Atg4al, Atg4al1, AUTL2, Autophagin-2, autophagy related 4A cysteine peptidase, autophagy related 4A, cysteine peptidase, HsAPG4A, LOC100038961, LOC100045570, RGD1588268 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atg4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- APG8-specific protease
- cysteine-type peptidase
- cysteine endopeptidase
- peptidase
- Peptidase family C54
- ATG4, F-type LIR motif
- protein binding
Pathways
Biological processes and signaling networks where the Atg4a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- abdominal aortic aneurysm
regulated by
- TP53
- TP73
- HSPG2
- 26S proteasome
- TP63
- S-allyl-L-cysteine sulfoxide
- F. tularensis Schu4
- GnRH analog
- Francisella novicida
- prednisolone
role in cell
- cell death
- autophagy by
- molecular cleavage in
- accumulation in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atg4a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein delipidation
- autophagic vacuole assembly
- piecemeal microautophagy of nucleus
- autophagy
- lipid metabolic process
- protein transport
- proteolysis
- protein processing
- C-terminal protein lipidation
- macromitophagy
- aggrephagy
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cysteine-type endopeptidase activity
- APG8-specific protease activity
- cysteine-type peptidase activity