Hspb6 Gene Summary [Mouse]
Predicted to enable several functions, including protein homodimerization activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including negative regulation of cardiac muscle cell apoptotic process; positive regulation of angiogenesis; and protein folding. Predicted to be located in several cellular components, including cytosol; mitochondrion; and nuclear speck. Predicted to be active in cytoplasm and nucleus. Is expressed in brain subventricular zone; lung; retina inner nuclear layer; retina outer nuclear layer; and smooth muscle tissue. Orthologous to human HSPB6 (heat shock protein family B (small) member 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Hspb6 |
| Official Name | heat shock protein, alpha-crystallin-related, B6 [Source:MGI Symbol;Acc:MGI:2685325] |
| Ensembl ID | ENSMUSG00000036854 |
| Bio databases IDs | |
| Aliases | heat shock protein, alpha-crystallin-related, B6 |
| Synonyms | FLJ32389, Gm479, heat shock protein, alpha-crystallin-related, B6, heat shock protein family B (small) member 6, heat shock protein, α-crystallin-related, B6, HEL55, Hsp20, p20, PPP1R91 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hspb6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta strand or sheet
- protein kinase binding
- alpha-crystallin Hsps/p23-like
- protein homodimerization
- Hsp20/alpha crystallin family
- protein binding
- chaperone binding
- Alpha crystallin A chain, N terminal
Pathways
Biological processes and signaling networks where the Hspb6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- neoplasia
- lung squamous cell carcinoma
- osteosarcoma
- urothelial bladder carcinoma
- transitional cell bladder cancer
- thyroid carcinoma
- epithelial thyroid cancer
- osteoarthritis
- prostate cancer
role in cell
- production in
- proliferation
- migration
- expression in
- growth
- invasiveness
- apoptosis
- cell death
- activation in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- Mitochondria
- cytosol
- nuclear speckles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hspb6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to heat
- negative regulation of apoptotic process
- chaperone-mediated protein folding
- protein refolding
- positive regulation of angiogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- mitochondrion
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding involved in protein folding
- chaperone binding
- unfolded protein binding
- structural constituent of eye lens