Rab13 Gene Summary [Mouse]
Predicted to enable GTP binding activity; GTPase activity; and protein kinase A catalytic subunit binding activity. Involved in endocytic recycling; endothelial cell chemotaxis; and protein localization to cell leading edge. Located in several cellular components, including bicellular tight junction; endocytic vesicle; and lamellipodium. Is expressed in several structures, including brain; early conceptus; meninges; secondary oocyte; and small intestine. Orthologous to human RAB13 (RAB13, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab13 |
| Official Name | RAB13, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1927232] |
| Ensembl ID | ENSMUSG00000027935 |
| Bio databases IDs | |
| Aliases | RAB13, member RAS oncogene family |
| Synonyms | 0610007N03Rik, B230212B15Rik, GIG4, RAB13, member RAS oncogene family |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- protein kinase binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- ADP-ribosylation factor family
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rab13 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- epithelial cancer
- severe acute respiratory syndrome
- hypoplasia
- prostate cancer
- prostatic carcinoma
role in cell
- invasion by
- number
- binding in
- adhesion
- outgrowth
- morphology
- chemotaxis by
- ruffling in
- organization
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- cytoplasmic vesicle membrane
- Cytoplasm
- cell periphery
- perinuclear region
- Golgi Apparatus
- intercellular junctions
- cytosol
- lateral plasma membrane
- Golgi membrane
- trans Golgi network
- growth cone
- neurites
- nerve ending
- recycling endosomes
- cytoplasmic vesicles
- endocytotic vesicle
- tight junctions
- secretory granules
- cell membrane leading edge
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- Golgi to plasma membrane transport
- exocytosis
- protein secretion
- cortical actin cytoskeleton organization
- cellular response to insulin stimulus
- protein kinase A signaling cascade
- endosomal transport
- tight junction assembly
- endothelial cell chemotaxis
- endocytic recycling
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- insulin-responsive compartment
- synaptic vesicle
- trans-Golgi network transport vesicle
- Golgi apparatus
- neuron projection
- plasma membrane
- endocytic vesicle
- tight junction
- trans-Golgi network
- endosome
- extracellular vesicular exosome
- cytosol
- cell junction
- cytoplasmic vesicle
- recycling endosome
- recycling endosome membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity