Gabarapl2 Gene Summary [Mouse]
Predicted to enable phosphatidylethanolamine binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cellular response to nitrogen starvation; macroautophagy; and negative regulation of proteasomal protein catabolic process. Predicted to act upstream of or within intra-Golgi vesicle-mediated transport. Located in Golgi membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human GABARAPL2 (GABA type A receptor associated protein like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabarapl2 |
| Official Name | gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2 [Source:MGI Symbol;Acc:MGI:1890602] |
| Ensembl ID | ENSMUSG00000031950 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2 |
| Synonyms | 0610012F20Rik, 2900019O08RIK, ATG8, ATG8C, FLC3A, GABA type A receptor associated protein like 2, GATE-16, GEF-2, LC3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gabarapl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- beta-tubulin binding
- ubiquitin protein ligase binding
- ATPase binding
- Ubl1_cv_Nsp3_N-like
- phosphatidylethanolamine binding
- protein binding
- receptor binding
Pathways
Biological processes and signaling networks where the Gabarapl2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- breast carcinoma
- non-insulin-dependent diabetes mellitus
- renal cell carcinoma
- glioblastoma
- glioblastoma cancer
- renal cell cancer
- infection by HIV-1
- productive infection by HIV-1
role in cell
- binding in
- expression in
- degradation in
- quantity
- size
- oncogene-induced senescence
- fusion
- autophagic flux in
- vesicle transport in
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Golgi Apparatus
- membrane compartment
- cytosol
- Golgi membrane
- autophagic vacuoles
- chromatin
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gabarapl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- positive regulation of ATPase activity
- autophagy
- protein transport
- intra-Golgi vesicle-mediated transport
- protein localization in endoplasmic reticulum
- mitochondrion degradation
- cellular response to nitrogen starvation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- cytosol
- cytoplasmic vesicle
- Golgi membrane
- Golgi apparatus
- autophagic vacuole
- autophagic vacuole membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylethanolamine binding
- ubiquitin protein ligase binding
- protein binding
- beta-tubulin binding
- SNARE binding
- GABA receptor binding
- ATPase binding
- microtubule binding