Gabarapl1 Gene Summary [Mouse]
Predicted to enable several functions, including Tat protein binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Involved in glycophagy. Predicted to be located in autophagosome; cell body; and dendrite. Predicted to be active in autophagosome membrane. Predicted to colocalize with mitochondrion. Is expressed in several structures, including adipose tissue; cerebral cortex; ganglia; sensory organ; and urinary system. Orthologous to several human genes including GABARAPL1 (GABA type A receptor associated protein like 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabarapl1 |
| Official Name | gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 [Source:MGI Symbol;Acc:MGI:1914980] |
| Ensembl ID | ENSMUSG00000030161 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 |
| Synonyms | 3110025G09Rik, 9130422N19Rik, APG8L, APG8-LIKE, ATG8, ATG8B, ATG8L, GABA type A receptor associated protein like 1, GEC1, GECI, LOC683917, MNCb-0091 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gabarapl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- phospholipid binding
- ubiquitin protein ligase binding
- cytoskeletal protein binding
- Ubl1_cv_Nsp3_N-like
- protein binding activity, bridging
- transcription factor binding
- protein binding
- receptor binding
Pathways
Biological processes and signaling networks where the Gabarapl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric adenocarcinoma
- gastric epithelial cancer
- rheumatoid arthritis
- glioblastoma
- glioblastoma cancer
- acute myocardial infarction
- chronic fatigue syndrome
- epithelial cancer
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
role in cell
- expression in
- proliferation
- formation
- formation in
- autophagy by
- transactivation in
- autophagy
- fusion
- maturation
- fusion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cilia
- perinuclear region
- Nucleus
- Plasma Membrane
- basal bodies
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- autophagic vacuoles
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gabarapl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- mitochondrion degradation
- cellular response to nitrogen starvation
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- mitochondrion
- cytosol
- Golgi apparatus
- endoplasmic reticulum
- autophagic vacuole
- autophagic vacuole membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- phosphatidylethanolamine binding
- protein binding
- ubiquitin protein ligase binding
- Tat protein binding
- beta-tubulin binding
- phospholipid binding
- GABA receptor binding