Hmox1 Gene Summary [Rat]
Enables several functions, including heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and phospholipase D activity. Involved in several processes, including intracellular signal transduction; negative regulation of apoptotic process; and regulation of gene expression. Located in caveola; endoplasmic reticulum; and nucleus. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); hepatic vascular disease (multiple); limb ischemia; and sciatic neuropathy. Biomarker of several diseases, including Sjogren's syndrome; artery disease (multiple); brain disease (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human HMOX1 (heme oxygenase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmox1 |
| Official Name | heme oxygenase 1 [Source:RGD Symbol;Acc:2806] |
| Ensembl ID | ENSRNOG00000014117 |
| Bio databases IDs | |
| Aliases | heme oxygenase 1 |
| Synonyms | bK286B10, D8Wsu38e, haemox, HEME OXYGENASE, Heme oxygenase 1, HEME OXYGENASE (DECYCLIZING) 1, Hemox, Heox, HEOXG, HMOX, HMOX1D, HO-1, HSP32, LOC103694288 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hmox1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipase D
- membrane-association domain
- nuclear localization sequence
- enzyme binding
- enzyme
- protein binding
- heme binding
- identical protein binding
- heme oxygenase
- heme oxygenase (decyclizing)
- reduced flavin or flavoprotein:oxygen oxidoreductase
- protein homodimerization
- structural molecule
Pathways
Biological processes and signaling networks where the Hmox1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Antioxidant Action of Vitamin C
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Docosahexaenoic Acid (DHA) Signaling
- Endothelin-1 Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Gαq Signaling
- HIF1α Signaling
- IL-10 Signaling
- IL-8 Signaling
- Iron homeostasis signaling pathway
- mTOR Signaling
- Neuroinflammation Signaling Pathway
- NRF2-mediated Oxidative Stress Response
- Pancreatic Adenocarcinoma Signaling
- Serotonin Receptor Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- tuberous sclerosis complex
- cancer
- perivascular fibrosis
- hepatic steatosis
- osteoporosis
- rheumatoid arthritis
- asthma
- retinal degeneration
phenotypes
- decreased systemic arterial blood pressure
- increased vasodilation
- Acute Lung Injury
- Altitude Sickness
- Alzheimer's Disease
- Behcet's disease
- Blast Crisis
- Brain Death
- Brain Injuries
- Carbon Monoxide Poisoning
- Carbon Tetrachloride Poisoning
- Chemical and Drug Induced Liver Injury
- Chronic Tubulointerstitial Nephropathy
- Coronary Disease
- Diabetes Mellitus Experimental
- Diabetic Cardiomyopathies
- Diabetic Nephropathies
- Dilatation Pathologic
- Endotoxemia
- Experimental Liver Cirrhosis
- Fever
- Graft Occlusion Vascular
- Helicobacter Infections
- Henoch-Schoenlein purpura
- Hyperoxic Lung Injury
- Hypertension Pregnancy-Induced
- Hypoxia-Ischemia Brain
- Insulin Resistance
- Intestinal Reperfusion Injury
- Kawasaki disease
- Kidney Reperfusion Injury
- Limb Ischemia
- Liver Reperfusion Injury
- Lung Reperfusion Injury
- Mammary Neoplasms Experimental
- Metabolic Syndrome
- Myocardial Ischemia
- Myocardial Reperfusion Injury
- Neointima
- Neonatal Hyperbilirubinemia
- Paraparesis
- Parkinsonian Disorders
- Pathologic Constriction
- perennial allergic rhinitis
- Pneumococcal Pneumonia
- Pulmonary Edema of Mountaineers
- Radiation Injuries Experimental
- Reperfusion Injury
- Retina Reperfusion Injury
- Rhabdomyolysis
- Right Ventricular Hypertrophy
- Shock Hemorrhagic
- Sjogren's Syndrome
- Spinal Cord Injuries
- Stroke
- Subarachnoid Hemorrhage
- Testis Reperfusion Injury
- Ventricular Fibrillation
- abdominal aortic aneurysm
- Acute Chest Syndrome
- acute kidney failure
- acute myeloid leukemia
- Adenocarcinoma
- adult respiratory distress syndrome
- Arteriosclerosis
- asthma
- Berylliosis
- Brain Edema
- Brain Ischemia
- Bronchiolitis Obliterans
- Carotid Artery Thrombosis
- Cerebral Infarction
- chronic myeloid leukemia
- chronic obstructive pulmonary disease
- colitis
- congestive heart failure
- Coronary Artery Disease
- Coronary Restenosis
- Cystic Fibrosis
- esophageal cancer
- factor VIII deficiency
- Hepatic Encephalopathy
- Hepatic Veno-Occlusive Disease
- Hepatopulmonary Syndrome
- hypertension
- Hyperthyroidism
- Ileus
- interstitial lung disease
- intracranial vasospasm
- lung disease
- middle cerebral artery infarction
- Myocardial Infarction
- newborn respiratory distress syndrome
- obstructive sleep apnea
- peptic ulcer disease
- Pneumonia
- Pneumothorax
- portal hypertension
- primary biliary cirrhosis
- Pulmonary Emphysema
- pulmonary hypertension
- pulmonary sarcoidosis
- renal hypertension
- Retinal Ischemia
- Sciatic Neuropathy
- sickle cell anemia
- Silicosis
- Status Epilepticus
- thrombosis
- toxic shock syndrome
- type 2 diabetes mellitus
- Varicocele
- viral pneumonia
- Hemorrhagic Shock
- Experimental Diabetes Mellitus
- Pregnancy-Induced Hypertension
- primary biliary cholangitis
- pulmonary venoocclusive disease
role in cell
- phosphorylation in
- proliferation
- production in
- expression in
- invasion by
- cell death
- cell viability
- degradation in
- migration
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
- microsome
- caveolae
- mitochondrial outer membrane
- nucleoplasm
- neurites
- smooth endoplasmatic reticulum
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hmox1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal iron ion homeostasis
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of angiogenesis
- positive regulation of cell migration involved in sprouting angiogenesis
- heme oxidation
- positive regulation of angiogenesis
- cellular iron ion homeostasis
- positive regulation of smooth muscle cell proliferation
- response to oxidative stress
- cellular response to heat
- angiogenesis
- cellular response to cadmium ion
- negative regulation of smooth muscle cell proliferation
- positive regulation of chemokine production
- macroautophagy
- intracellular signal transduction
- low-density lipoprotein particle clearance
- cellular response to cisplatin
- positive regulation of macroautophagy
- erythrocyte homeostasis
- heme catabolic process
- response to nicotine
- response to hydrogen peroxide
- regulation of transcription from RNA polymerase II promoter
- wound healing involved in inflammatory response
- negative regulation of leukocyte migration
- smooth muscle hyperplasia
- cellular response to arsenic-containing substance
- endothelial cell proliferation
- negative regulation of macroautophagy
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- extracellular space
- perinuclear region of cytoplasm
- membrane
- cytosol
- endoplasmic reticulum
- mitochondrial outer membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- metal ion binding
- heme oxygenase (decyclizing) activity
- structural molecule activity
- heme binding
- enzyme binding