Hmox1 Gene Summary [Mouse]
Predicted to enable several functions, including heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and protein homodimerization activity. Involved in negative regulation of cytokine production involved in inflammatory response. Acts upstream of or within several processes, including cellular response to cadmium ion; cellular response to cisplatin; and regulation of macroautophagy. Located in nucleus. Is active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study hemochromatosis and malaria. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and sickle cell anemia. Orthologous to human HMOX1 (heme oxygenase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmox1 |
| Official Name | heme oxygenase 1 [Source:MGI Symbol;Acc:MGI:96163] |
| Ensembl ID | ENSMUSG00000005413 |
| Bio databases IDs | |
| Aliases | heme oxygenase 1 |
| Synonyms | bK286B10, D8Wsu38e, haemox, HEME OXYGENASE, Heme oxygenase 1, HEME OXYGENASE (DECYCLIZING) 1, Hemox, Heox, HEOXG, HMOX, HMOX1D, HO-1, HSP32, LOC103694288 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hmox1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipase D
- membrane-association domain
- nuclear localization sequence
- enzyme binding
- enzyme
- protein binding
- heme binding
- identical protein binding
- heme oxygenase
- heme oxygenase (decyclizing)
- reduced flavin or flavoprotein:oxygen oxidoreductase
- protein homodimerization
- structural molecule
Pathways
Biological processes and signaling networks where the Hmox1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Antioxidant Action of Vitamin C
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Docosahexaenoic Acid (DHA) Signaling
- Endothelin-1 Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Gαq Signaling
- HIF1α Signaling
- IL-10 Signaling
- IL-8 Signaling
- Iron homeostasis signaling pathway
- mTOR Signaling
- Neuroinflammation Signaling Pathway
- NRF2-mediated Oxidative Stress Response
- Pancreatic Adenocarcinoma Signaling
- Phagosome Formation
- Serotonin Receptor Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- tuberous sclerosis complex
- cancer
- perivascular fibrosis
- hepatic steatosis
- osteoporosis
- rheumatoid arthritis
- asthma
- retinal degeneration
role in cell
- phosphorylation in
- proliferation
- production in
- expression in
- invasion by
- cell death
- cell viability
- degradation in
- migration
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
- microsome
- caveolae
- mitochondrial outer membrane
- nucleoplasm
- neurites
- smooth endoplasmatic reticulum
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hmox1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal iron ion homeostasis
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of angiogenesis
- positive regulation of cell migration involved in sprouting angiogenesis
- heme oxidation
- positive regulation of angiogenesis
- cellular iron ion homeostasis
- positive regulation of smooth muscle cell proliferation
- response to oxidative stress
- cellular response to heat
- angiogenesis
- cellular response to cadmium ion
- negative regulation of smooth muscle cell proliferation
- positive regulation of chemokine production
- macroautophagy
- intracellular signal transduction
- low-density lipoprotein particle clearance
- cellular response to cisplatin
- positive regulation of macroautophagy
- erythrocyte homeostasis
- heme catabolic process
- response to nicotine
- response to hydrogen peroxide
- regulation of transcription from RNA polymerase II promoter
- wound healing involved in inflammatory response
- negative regulation of leukocyte migration
- smooth muscle hyperplasia
- cellular response to arsenic-containing substance
- endothelial cell proliferation
- negative regulation of macroautophagy
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- extracellular space
- perinuclear region of cytoplasm
- membrane
- cytosol
- endoplasmic reticulum
- mitochondrial outer membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- metal ion binding
- heme oxygenase (decyclizing) activity
- structural molecule activity
- heme binding
- enzyme binding