Acta2 Gene Summary [Rat]
Predicted to enable protein kinase binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of hepatic stellate cell activation; and positive regulation of hepatic stellate cell contraction. Located in basement membrane and stress fiber. Biomarker of rheumatic heart disease. Human ortholog(s) of this gene implicated in Moyamoya disease and thoracic aortic aneurysm. Orthologous to human ACTA2 (actin alpha 2, smooth muscle). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acta2 |
| Official Name | actin alpha 2, smooth muscle [Source:RGD Symbol;Acc:621676] |
| Ensembl ID | ENSRNOG00000058039 |
| Bio databases IDs | |
| Aliases | actin alpha 2, smooth muscle |
| Synonyms | 0610041G09RIK, actin alpha 2, smooth muscle, actin alpha 2, smooth muscle, aorta, actin α 2, smooth muscle, actin α 2, smooth muscle, aorta, ACTSA, Actvs, Alpha-SMA, Alpha-smooth muscle actin, a-SMA, FLJ45296, RGD: 621676, Similar to vascular alpha actin, Similar to vascular α actin, SMA, SMAalpha, SMalphaA, SM Alpha Actin, SMDYS, SMOOTH MUSCLE alpha ACTIN, SMOOTH MUSCLE α ACTIN, SM α Actin, Vascular Smooth Muscle Alpha-Actin, Vascular Smooth Muscle α-Actin, α-actin 2, α actin vsm, α-SMA, α-smooth muscle actin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acta2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- Actin
- protein binding
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Acta2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agranulocyte Adhesion and Diapedesis
- Calcium Signaling
- Caveolar-mediated Endocytosis Signaling
- Cellular Effects of Sildenafil (Viagra)
- Clathrin-mediated Endocytosis Signaling
- Death Receptor Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Gap Junction Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- IL-17A Signaling in Fibroblasts
- ILK Signaling
- Leukocyte Extravasation Signaling
- Mechanisms of Viral Exit from Host Cells
- MSP-RON Signaling Pathway
- NRF2-mediated Oxidative Stress Response
- Regulation of Actin-based Motility by Rho
- Remodeling of Epithelial Adherens Junctions
- RhoA Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- TEC Kinase Signaling
- Tight Junction Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- chronic sinusitis
- neoplasia
- breast carcinoma
- schizophrenia
- fibrosis
- facioscapulohumeral muscular dystrophy
- prostate cancer
- familial thoracic aortic aneurysm type 6
- Loeys-Dietz syndrome
role in cell
- proliferation
- production in
- migration
- expression in
- invasion by
- transendothelial migration
- transdifferentiation
- contractility
- disassembly
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- cytoskeleton
- cell surface
- filamentous network
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- cytosol
- myofibrils
- actin stress fibers
- membrane processes
- filopodia
- perikaryon
- basement membrane
- lamellipodia
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acta2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of hepatic stellate cell activation
- cellular response to transforming growth factor beta stimulus
- vascular smooth muscle contraction
- positive regulation of gene expression
- glomerular mesangial cell development
- positive regulation of ERK1 and ERK2 cascade
- mesenchyme migration
- response to virus
- juxtaglomerular apparatus development
- regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- motile cilium
- basement membrane
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- cell body
- stress fiber
- actin cytoskeleton
- filopodium
- cytosol
- macromolecular complex
- smooth muscle contractile fiber
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- hydrolase activity