Megf10 Gene Summary [Mouse]
Enables Notch binding activity. Involved in several processes, including myoblast development; positive regulation of myoblast proliferation; and skeletal muscle satellite cell proliferation. Acts upstream of or within apoptotic process involved in development; engulfment of apoptotic cell; and recognition of apoptotic cell. Located in phagocytic cup. Is expressed in several structures, including brain; heart; retina layer; skeletal muscle tissue; and testis. Human ortholog(s) of this gene implicated in congenital myopathy 10B and early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome. Orthologous to human MEGF10 (multiple EGF like domains 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Megf10 |
| Official Name | multiple EGF-like-domains 10 [Source:MGI Symbol;Acc:MGI:2685177] |
| Ensembl ID | ENSMUSG00000024593 |
| Bio databases IDs | |
| Aliases | multiple EGF-like-domains 10 |
| Synonyms | 3000002B06RIK, CMYO10A, CMYO10B, CMYP10A, CMYP10B, EMARDD, Gm331, LOC102723571, multiple EGF-like-domains 10, SR-F3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Megf10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Laminin-type epidermal growth factor-like domai
- binding protein
- scavenger receptor
- intracellular domain
- EMI domain
- protein binding
- transmembrane receptor
- notch binding
- Laminin EGF domain
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- early-onset myopathy, areflexia, respiratory distress, and dysphagia, mild variant
- neurobehavioral deficit
- Alzheimer disease
- early-onset myopathy, areflexia, respiratory distress, and dysphagia
- brain damage
- MEGF10-related myopathy
- rectum cancer
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
regulates
- MEGF10
- C1Q
role in cell
- proliferation
- migration
- activation
- autophagy in
- differentiation
- development
- phagocytosis
- number
- engulfment
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- phagocytic cups
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Megf10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle cell development
- positive regulation of cell-cell adhesion
- apoptotic cell clearance
- engulfment of apoptotic cell
- recognition of apoptotic cell
- myoblast development
- regulation of muscle cell differentiation
- myoblast migration
- satellite cell activation
- regulation of skeletal muscle tissue development
- satellite cell differentiation
- positive regulation of myoblast proliferation
- muscle cell proliferation
- homotypic cell-cell adhesion
- satellite cell proliferation
Cellular Component
Where in the cell the gene product is active
- cell projection
- phagocytic cup
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- scavenger receptor activity
- Notch binding
- complement component C1q binding