Dhx16 Gene Summary [Mouse]
Predicted to enable several functions, including helicase activity; pattern recognition receptor activity; and ubiquitin binding activity. Predicted to be involved in antiviral innate immune response and mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of U2-type precatalytic spliceosome. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and integumental system. Orthologous to human DHX16 (DEAH-box helicase 16). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dhx16 |
| Official Name | DEAH (Asp-Glu-Ala-His) box polypeptide 16 [Source:MGI Symbol;Acc:MGI:1916442] |
| Ensembl ID | ENSMUSG00000024422 |
| Bio databases IDs | |
| Aliases | DEAH (Asp-Glu-Ala-His) box polypeptide 16 |
| Synonyms | 2410006N22Rik, DBP2, DDX16, DEAH-box helicase 16, KIAA0577, mKIAA0577, NMOAS, PRO2014, Prp2, PRP8, PRPF2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dhx16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helicase associated domain (HA2)
- Oligonucleotide/oligosaccharide-binding (OB)-fold
- signaling receptor activity
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- ubiquitin binding
- enzyme
- protein binding
- Helicase conserved C-terminal domain
- RNA helicase
- Helicase associated domain (HA2) Add an annotation
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dhx16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- spliceosomal complex
- U2-type precatalytic spliceosome
- intracellular
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA binding
- ubiquitin binding
- RNA helicase activity
- helicase activity
- binding, bridging