Snrnp200 Gene Summary [Mouse]
On February 19, 2002, this locus was switched from human to mouse. The source accession, Z70200.1, is almost identical to the mouse BAC clone AC074224, and it matches the mouse cDNA accession BC011390 as well. The human gene is LocusID 23020. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | Snrnp200 |
| Official Name | small nuclear ribonucleoprotein 200 (U5) [Source:MGI Symbol;Acc:MGI:2444401] |
| Ensembl ID | ENSMUSG00000003660 |
| Bio databases IDs | |
| Aliases | small nuclear ribonucleoprotein 200 (U5) |
| Synonyms | A330064G03Rik, ASCC3L1, BRR2, HELIC2, KIAA0788, RP33, small nuclear ribonucleoprotein 200 (U5), small nuclear ribonucleoprotein U5 subunit 200, U5-200, U5-200-KD, U5 snRNP-specific 200kD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Snrnp200 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- seven helix bundle domain
- winged helix turn helix domain
- helicase
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- linker domain
- Domain of unknown function in Sec63p, Brr2p and other proteins
- enzyme
- protein binding
- N-terminal helicase PWI domain
- identical protein binding
- RNA helicase
- Sec63 Brl domain
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- immunoglobulin-like protein domain
- RecA-like ATPase domain
- helix-loop-helix domain
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Snrnp200 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinitis pigmentosa type 33
- retinal dystrophy
- autosomal dominant retinitis pigmentosa
- major depression
- rheumatoid arthritis
- schizophrenia
- retinitis pigmentosa
- SNRNP200-related dominant retinopathy
role in cell
- proliferation
- cell viability
- splicing by
- alternative splicing in
- processing in
- homologous recombination in
- prometaphase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- cilia
- Plasma Membrane
- spliceosomes
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Snrnp200 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osteoblast differentiation
- spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
- nuclear mRNA splicing, via spliceosome
- cis assembly of pre-catalytic spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- membrane
- U4/U6 x U5 tri-snRNP complex
- U5 snRNP
- U2-type catalytic step 1 spliceosome
- spliceosomal complex
- U2-type precatalytic spliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- protein binding
- RNA binding
- RNA helicase activity
- helicase activity