Hoxc6 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification and embryonic skeletal system development. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; musculoskeletal system; and nervous system. Orthologous to human HOXC6 (homeobox C6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Hoxc6 |
| Official Name | homeobox C6 [Source:MGI Symbol;Acc:MGI:96197] |
| Ensembl ID | ENSMUSG00000001661 |
| Bio databases IDs | |
| Aliases | homeobox C6 |
| Synonyms | CP25, HHO.C8, homeobox C6, HOX3, Hox-3.3, HOX3C, Hox-6.1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hoxc6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical cancer
- organismal death
- neoplasia
- gastroesophageal reflux
- Huntington disease
- prostate cancer
- clear cell sarcoma of the kidney
- renal cancer
- soft tissue sarcoma cancer
- hip fracture
role in cell
- expression in
- proliferation
- apoptosis
- growth
- cell viability
- cell proliferation
- transactivation in
- S phase progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hoxc6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anterior/posterior pattern specification
- embryonic skeletal system development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity