Grb10 Gene Summary [Mouse]
Enables insulin receptor binding activity and signaling receptor complex adaptor activity. Involved in several processes, including negative regulation of D-glucose import; negative regulation of signal transduction; and positive regulation of cold-induced thermogenesis. Acts upstream of or within with a negative effect on ERK1 and ERK2 cascade and gene expression. Acts upstream of or within insulin-like growth factor receptor signaling pathway and vascular associated smooth muscle cell migration. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; musculoskeletal system; and sensory organ. Orthologous to human GRB10 (growth factor receptor bound protein 10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grb10 |
| Official Name | growth factor receptor bound protein 10 [Source:MGI Symbol;Acc:MGI:103232] |
| Ensembl ID | ENSMUSG00000020176 |
| Bio databases IDs | |
| Aliases | growth factor receptor bound protein 10 |
| Synonyms | 5730571D09Rik, GRB-IR, growth factor receptor bound protein 10, IRBP, MEG1, mKIAA0207, RGD1566234, RSS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grb10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- insulin receptor binding
- between pleckstrin homology and SH2 domain
- protein binding activity, bridging
- phosphotyrosine binding
- protein binding
- Pleckstrin homology-like domain
- identical protein binding
- BPS (Between PH and SH2)
- proline rich domain
- Sh3 domain binding motif
- receptor signaling complex scaffold protein
- Ubl1_cv_Nsp3_N-like
- Ras-binding domain
- PH domain
- Src homology 2 (SH2) domain
Pathways
Biological processes and signaling networks where the Grb10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- kidney carcinoma
- renal cancer
- epithelial cancer
- rheumatoid arthritis
- renal clear cell adenocarcinoma
role in cell
- apoptosis
- expression in
- induction in
- phosphorylation in
- growth
- survival
- S phase
- transformation
- tyrosine phosphorylation in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Plasma Membrane
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grb10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ERK1 and ERK2 cascade
- insulin receptor signaling pathway
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- insulin-like growth factor receptor signaling pathway
- negative regulation of glucose import
- gene expression
- negative regulation of Wnt receptor signaling pathway
- negative regulation of insulin receptor signaling pathway
- negative regulation of phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- insulin receptor binding
- receptor signaling complex scaffold activity