Gulp1 Gene Summary [Mouse]
Predicted to be involved in apoptotic process and lipid transport. Predicted to act upstream of or within phagocytosis, engulfment. Predicted to be located in cytoplasm. Is expressed in genitourinary system. Orthologous to human GULP1 (GULP PTB domain containing engulfment adaptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gulp1 |
| Official Name | GULP, engulfment adaptor PTB domain containing 1 [Source:MGI Symbol;Acc:MGI:1920407] |
| Ensembl ID | ENSMUSG00000056870 |
| Bio databases IDs | |
| Aliases | GULP, engulfment adaptor PTB domain containing 1 |
| Synonyms | 3110030A04Rik, 5730529O06Rik, CED-6, GULP, Gulp-2, GULP, engulfment adaptor PTB domain containing 1, GULP PTB domain containing engulfment adaptor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gulp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucine zipper domain
- ZIP_TSC22D-like
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- proline rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- peripheral arterial disease
regulates
- glycosphingolipid
- cholesterol
- GULP1
- Ced1
role in cell
- cell death
- differentiation
- phagocytosis
- number
- abnormal morphology
- phagocytosis by
- function
- engulfment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- clathrin-coated structures
- cell surface
- Plasma Membrane
- cytosol
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gulp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- phagocytosis, engulfment
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm