Chst2 Gene Summary [Mouse]
Enables sulfotransferase activity. Involved in positive regulation of leukocyte tethering or rolling. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in trans-Golgi network. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human CHST2 (carbohydrate sulfotransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chst2 |
| Official Name | carbohydrate sulfotransferase 2 [Source:MGI Symbol;Acc:MGI:1891160] |
| Ensembl ID | ENSMUSG00000033350 |
| Bio databases IDs | |
| Aliases | carbohydrate sulfotransferase 2 |
| Synonyms | AI428561, AW121776, C130041E03RIK, C6ST, Carbohydrate sulfotransferase 2, Carbohydrate sulphotransferase 2, Chts2, GlcNAc6ST, glcNAc6ST-1, Gn6st, Gn6ST-1, GST-2, HEL-S-75, LOC100044297 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chst2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- stem region
- sulfotransferase
- N-acetylglucosamine-6-O-sulfotransferase
- enzyme
Pathways
Biological processes and signaling networks where the Chst2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- androgenic alopecia
- sneeze
role in cell
- quantity
- migration
- cell tethering or rolling by
- regrowth
- number
- homing
- cell rolling
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- cytosol
- Golgi membrane
- trans Golgi network
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chst2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- inflammatory response
- sulfur compound metabolic process
- N-acetylglucosamine metabolic process
- keratan sulfate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- cytosol
- Golgi membrane
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- N-acetylglucosamine 6-O-sulfotransferase activity
- sulfotransferase activity