Canx Gene Summary [Mouse]
Predicted to enable apolipoprotein binding activity; calcium ion binding activity; and ionotropic glutamate receptor binding activity. Involved in clathrin-dependent endocytosis and synaptic vesicle endocytosis. Located in endoplasmic reticulum quality control compartment and nuclear membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; intestine; and musculature. Orthologous to human CANX (calnexin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Canx |
| Official Name | calnexin [Source:MGI Symbol;Acc:MGI:88261] |
| Ensembl ID | ENSMUSG00000020368 |
| Bio databases IDs | |
| Aliases | calnexin |
| Synonyms | 1110069N15Rik, Calnexin, Cell adhesion molecule with homology to l1cam precursor, CNX, D11Ertd153e, IP90, P90, Similar to calnexin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Canx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ER retention sequence
- Calreticulin family
- cytoplasmic domain
- calcium ion binding
- tail domain
- protein binding
- ionotropic glutamate receptor binding
- glycoprotein binding domain
Pathways
Biological processes and signaling networks where the Canx gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric carcinoma
- gastric epithelial cancer
- preeclampsia
- growth failure
- Alzheimer disease
- aortic valve calcification
- ataxia
- Nonaka myopathy
- experimental autoimmune encephalomyelitis
- positive geotaxis
role in cell
- expression in
- quantity
- apoptosis
- proliferation
- binding in
- migration
- formation in
- invasion by
- molecular cleavage in
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- microsomal fraction
- myelin enriched fraction
- endoplasmic reticulum fraction
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- endoplasmic reticulum mitochondria contact site
- endoplasmic reticulum tubules
- cell surface
- cell borders
- intracellular space
- perinuclear region
- membrane surface
- cellular membrane
- focal adhesions
- ribosome
- Nucleus
- Plasma Membrane
- vesicles
- Endoplasmic Reticulum
- Mitochondria
- lipid droplets
- granules
- ER-to-Golgi intermediate compartment
- cytosol
- endoplasmic reticulum compartments
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- microsome
- presynaptic membrane
- postsynaptic membrane
- Golgi membrane
- mitochondria-associated membranes
- perinuclear space
- nuclear envelope
- dendritic spines
- synaptic vesicles
- growth cone
- synaptosomes
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- rough endoplasmic reticulum membrane
- membrane processes
- perikaryon
- axons
- dendrites
- phagosomes
- phagocytic cups
- detergent-soluble fraction
- endosomes and endoplasmic reticulum fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Canx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- clathrin-mediated endocytosis
- viral protein processing
- synaptic vesicle endocytosis
- protein folding
- protein secretion
- protein folding in endoplasmic reticulum
Cellular Component
Where in the cell the gene product is active
- melanosome membrane
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- nuclear membrane
- mitochondrial membrane
- extracellular vesicular exosome
- membrane
- endoplasmic reticulum quality control compartment
- ER-mitochondrion membrane contact site
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- calcium ion binding
- unfolded protein binding
- carbohydrate binding