Lrrn3 Gene Summary [Mouse]
Acts upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be part of clathrin adaptor complex. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; peripheral nervous system ganglion; respiratory system; and sensory organ. Orthologous to human LRRN3 (leucine rich repeat neuronal 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrrn3 |
| Official Name | leucine rich repeat protein 3, neuronal [Source:MGI Symbol;Acc:MGI:106036] |
| Ensembl ID | ENSMUSG00000036295 |
| Bio databases IDs | |
| Aliases | leucine rich repeat protein 3, neuronal |
| Synonyms | FIGLER5, leucine rich repeat neuronal 3, leucine rich repeat protein 3, neuronal, NLRR-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrrn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- clathrin binding domain
- protein phosphatase 1 regulatory subunit 42
- immunoglobulin domain
- Immunoglobulin I-set domain
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- protein binding
- Fibronectin type 3 domain
- binding protein
- FN3
- Immunoglobulin like
- Leucine rich repeat N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- idiopathic pulmonary fibrosis
- melanoma
- melanoma cancer
- sepsis
- septic shock
regulates
- MAPK
- LRRN3
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrrn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- extracellular matrix