Paf1 Gene Summary [Mouse]
Enables chromatin binding activity. Involved in several processes, including cellular response to lipopolysaccharide; endodermal cell fate commitment; and negative regulation of transcription by RNA polymerase II. Part of Cdc73/Paf1 complex. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human PAF1 (PAF1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Paf1 |
| Official Name | Paf1, RNA polymerase II complex component [Source:MGI Symbol;Acc:MGI:1923988] |
| Ensembl ID | ENSMUSG00000003437 |
| Bio databases IDs | |
| Aliases | Paf1, RNA polymerase II complex component |
| Synonyms | 5730511K23RIK, F23149 1, PAF1 homolog, Paf1/RNA polymerase II complex component, Paf1, RNA polymerase II complex component, PD2, RGD1306219 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Paf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Paf1
- enzyme binding
- chromatin binding
- Serine-rich region of AP3B1, clathrin-adaptor complex
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- infection by Influenza A virus subtype H1N1
role in cell
- expression in
- differentiation
- migration
- cell death
- growth
- proliferation
- binding in
- recruitment in
- transactivation in
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- intracellular membrane-bounded organelle
- Cytoplasm
- cellular membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Paf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- stem cell maintenance
- negative regulation of myeloid cell differentiation
- cellular response to lipopolysaccharide
- endodermal cell fate commitment
- mRNA 3'-end processing
- Wnt receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- protein localization to nucleus
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- Cdc73/Paf1 complex
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding
- RNA polymerase II core binding