Max Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of DNA-templated transcription. Located in nucleus. Part of Myc-Max complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; lens; and upper jaw. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Orthologous to human MAX (MYC associated factor X). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Max |
| Official Name | Max protein [Source:MGI Symbol;Acc:MGI:96921] |
| Ensembl ID | ENSMUSG00000059436 |
| Bio databases IDs | |
| Aliases | Max protein |
| Synonyms | bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8, Max protein, MYC associated factor X, Myn, PDMCS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Max often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- dimerization domain
- DNA binding domain
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- alpha helix
- transcription factor binding
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- phosphorylation site
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- basic helix-loop-helix-leucine zipper domain
- binding protein
- double-stranded DNA binding
- helix loop helix domain
- Helix-loop-helix DNA-binding domain
- basic domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Max gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- neoplasia
- pheochromocytoma
- pheochromocytoma formation
- hereditary cancer-predisposing syndrome
- Klatskin tumor
- cholangiocarcinoma cancer
- hereditary paraganglioma-pheochromocytoma syndrome
- Waldenström macroglobulinemia
- polydactyly-macrocephaly syndrome
role in cell
- expression in
- binding in
- apoptosis
- growth
- proliferation
- migration
- transactivation in
- degeneration
- S phase
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- PML nuclear bodies
- chromatin
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Max gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- protein-DNA complex
- Mad-Max complex
- chromatin
- Myc-Max complex
- nucleoplasm
- MLL1 complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- E-box binding