H2-DMa Gene Summary [Mouse]
Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Involved in positive regulation of germinal center formation and positive regulation of humoral immune response. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; chaperone cofactor-dependent protein refolding; and positive thymic T cell selection. Located in endosome membrane; lysosomal membrane; and multivesicular body. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human HLA-DMA (major histocompatibility complex, class II, DM alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | H2-DMa |
| Official Name | histocompatibility 2, class II, locus DMa [Source:MGI Symbol;Acc:MGI:95921] |
| Ensembl ID | ENSMUSG00000037649 |
| Bio databases IDs | |
| Aliases | histocompatibility 2, class II, locus DMa |
| Synonyms | CLASS II HISTOCOMPATIBILITY ANTIGEN M alpha subunit precursor, CLASS II HISTOCOMPATIBILITY ANTIGEN M α subunit precursor, D6S222E, DMA, DMA1, H2-dm, H2-DMa, H-2Ma, histocompatibility 2, class II, locus DMa, HLADM, LOC108348072, major histocompatibility complex, class II, DM alpha, major histocompatibility complex, class II, DM α, Mhcii dma, RING6, RT1 class II, locus DMa, RT1-DMa, RT1.DMa, RT1.Ma |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse H2-Dma often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- binding protein
- immunoglobulin domain
- immunoglobulin-like protein domain
- Class II histocompatibility antigen, alpha domain
- protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the H2-Dma gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- delayed hypersensitive reaction
- diabetic nephropathy
- rheumatoid arthritis
- schizophrenia
- septic shock
- Sjogren syndrome keratoconjunctivitis sicca
- insulin-dependent diabetes mellitus
- dextran sodium sulfate-induced colitis
- pervasive developmental disorder
role in cell
- binding
- expression in
- proliferation
- apoptosis
- quantity
- function
- activation
- differentiation
- number
- selection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular membrane-bounded organelle
- cell surface
- intracellular space
- lysosome
- lysosome membrane
- endosomal membrane
- late endosomes
- endocytotic vesicle
- multivesicular bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse H2-Dma gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of T cell activation
- peptide antigen assembly with MHC class II protein complex
- adaptive immune response
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- positive regulation of immune response
Cellular Component
Where in the cell the gene product is active
- MHC class II protein complex
- late endosome membrane
- intracellular membrane-bounded organelle
- membrane
- lysosomal membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- peptide antigen binding
- MHC class II protein complex binding