Slc51b Gene Summary [Mouse]
Enables bile acid transmembrane transporter activity and protein heterodimerization activity. Involved in several processes, including bile acid and bile salt transport; positive regulation of establishment of protein localization; and positive regulation of protein glycosylation. Located in basolateral plasma membrane. Part of protein-containing complex. Is expressed in liver and small intestine. Orthologous to human SLC51B (SLC51 subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc51b |
| Official Name | solute carrier family 51, beta subunit [Source:MGI Symbol;Acc:MGI:3582052] |
| Ensembl ID | ENSMUSG00000053862 |
| Bio databases IDs | |
| Aliases | solute carrier family 51, beta subunit |
| Synonyms | OSTB, OSTBETA, PBAM2, RGD1565748, SLC51A1BP, SLC51 subunit beta, SLC51 subunit β, solute carrier family 51, beta subunit, solute carrier family 51, β subunit |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc51b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Organic solute transporter subunit beta protein
- protein binding
- bile acid transporter
- protein heterodimerization
- transporter
Pathways
Biological processes and signaling networks where the Slc51b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal adenoma
- colorectal adenoma formation
- primary bile acid malabsorption type 2
- cholelithiasis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- primary biliary cirrhosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membranes
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- basolateral membrane
- basal membrane
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc51b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein targeting to membrane
- transmembrane transport
- regulation of protein stability
- positive regulation of protein exit from endoplasmic reticulum
- bile acid secretion
- positive regulation of protein glycosylation
- bile acid and bile salt transport
Cellular Component
Where in the cell the gene product is active
- membrane
- macromolecular complex
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- bile acid transmembrane transporter activity
- protein binding
- protein heterodimerization activity
- transporter activity