Vdr Gene Summary [Mouse]
Enables DNA binding activity and nuclear receptor activity. Involved in regulation of calcidiol 1-monooxygenase activity. Acts upstream of or within several processes, including intestinal absorption; mammary gland development; and positive regulation of apoptotic process involved in mammary gland involution. Predicted to be located in several cellular components, including T-tubule; chromatin; and nuclear lumen. Predicted to be part of RNA polymerase II transcription regulator complex and receptor complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; metanephros; nervous system; sensory organ; and skeleton. Used to study osteoporosis and rickets. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); liver disease (multiple); lung disease (multiple); and melanoma (multiple). Orthologous to human VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vdr |
| Official Name | vitamin D (1,25-dihydroxyvitamin D3) receptor [Source:MGI Symbol;Acc:MGI:103076] |
| Ensembl ID | ENSMUSG00000022479 |
| Bio databases IDs | |
| Aliases | vitamin D (1,25-dihydroxyvitamin D3) receptor |
| Synonyms | NR1I1, PPP1R163, vitamin D (1,25-dihydroxyvitamin D3) receptor, vitamin D receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vdr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- A-box
- zinc finger DNA binding domain
- transcription regulator
- vitamin D binding domain
- steroid hormone receptor
- A/B region
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- VDR ligand binding domain
- AF-2 transcription activation domain
- H helix
- hormone binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- nuclear receptor ligand binding domain
- ligand-binding domain
- ligand-dependent nuclear receptor
- loop domain
- T-box domain
- dimerization domain
- vitamin D binding
- DNA binding domain
- nucleic acid binding
- alpha helix
- protein binding
- sequence-specific DNA binding
- DNA binding
- steroid binding
- binding protein
- double-stranded DNA binding
- hinge domain
- retinoid X receptor binding
- zinc finger domain
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Pathways
Biological processes and signaling networks where the Vdr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pulmonary emphysema
- chronic obstructive pulmonary disease
- neoplasia
- hyperphosphatemia
- end stage renal disease
- chronic kidney disease
- undernutrition
- burn
- nephritis
- obesity
role in cell
- recruitment
- expression in
- growth
- production in
- apoptosis
- phosphorylation in
- number
- differentiation
- migration
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- nuclear lipid microdomain
- Cytoplasm
- cell surface
- perinuclear region
- Plasma Membrane
- Mitochondria
- cytosol
- caveolae
- nuclear foci
- dense fibrillar component
- nucleoplasm
- nuclear matrix
- growth cone
- neurites
- transverse tubules
- filopodia
- cell membrane leading edge
- chromatin
- perikaryon
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vdr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal development
- negative regulation of cell proliferation
- mammary gland branching involved in pregnancy
- decidualization
- lactation
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of keratinocyte proliferation
- negative regulation of transcription from RNA polymerase II promoter
- intestinal absorption
- skeletal system development
- negative regulation of transcription, DNA-dependent
- vitamin D receptor signaling pathway
- calcium ion transport
- positive regulation of vitamin D receptor signaling pathway
- phosphate ion transmembrane transport
- positive regulation of bone mineralization
- mRNA transcription from RNA polymerase II promoter
- positive regulation of keratinocyte differentiation
- apoptotic process involved in mammary gland involution
- positive regulation of apoptotic process involved in mammary gland involution
- cell morphogenesis
- regulation of calcidiol 1-monooxygenase activity
- cellular calcium ion homeostasis
- positive regulation of gene expression
- cell differentiation
- positive regulation of vitamin D 24-hydroxylase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- receptor complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- zinc ion binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- vitamin D response element binding
- retinoid X receptor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity