Vdr Gene Summary [Mouse]
Enables DNA binding activity and nuclear receptor activity. Involved in regulation of calcidiol 1-monooxygenase activity. Acts upstream of or within several processes, including intestinal absorption; mammary gland development; and positive regulation of apoptotic process involved in mammary gland involution. Predicted to be located in several cellular components, including T-tubule; chromatin; and nuclear lumen. Predicted to be part of RNA polymerase II transcription regulator complex and receptor complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; metanephros; nervous system; sensory organ; and skeleton. Used to study osteoporosis and rickets. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); liver disease (multiple); lung disease (multiple); and melanoma (multiple). Orthologous to human VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vdr |
| Official Name | vitamin D (1,25-dihydroxyvitamin D3) receptor [Source:MGI Symbol;Acc:MGI:103076] |
| Ensembl ID | ENSMUSG00000022479 |
| Bio databases IDs | |
| Aliases | vitamin D (1,25-dihydroxyvitamin D3) receptor |
| Synonyms | NR1I1, PPP1R163, vitamin D (1,25-dihydroxyvitamin D3) receptor, vitamin D receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vdr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- A-box
- zinc finger DNA binding domain
- transcription regulator
- vitamin D binding domain
- steroid hormone receptor
- A/B region
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- VDR ligand binding domain
- AF-2 transcription activation domain
- H helix
- hormone binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- nuclear receptor ligand binding domain
- ligand-binding domain
- ligand-dependent nuclear receptor
- loop domain
- T-box domain
- dimerization domain
- vitamin D binding
- DNA binding domain
- nucleic acid binding
- alpha helix
- protein binding
- sequence-specific DNA binding
- DNA binding
- steroid binding
- binding protein
- double-stranded DNA binding
- hinge domain
- retinoid X receptor binding
- zinc finger domain
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Pathways
Biological processes and signaling networks where the Vdr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pulmonary emphysema
- chronic obstructive pulmonary disease
- neoplasia
- hyperphosphatemia
- end stage renal disease
- chronic kidney disease
- undernutrition
- burn
- nephritis
- obesity
phenotypes
- abnormal T cell number
- abnormal blood homeostasis
- abnormal bone mineralization
- abnormal bone ossification
- abnormal bone structure
- abnormal chemokine secretion
- abnormal chondrocyte morphology
- abnormal coat/ hair morphology
- abnormal colon morphology
- abnormal dendritic cell differentiation
- abnormal enzyme/coenzyme activity
- abnormal epidermis stratum granulosum morphology
- abnormal estrous cycle
- abnormal fat-soluble vitamin level
- abnormal female reproductive system morphology
- abnormal femur morphology
- abnormal fertility/fecundity
- abnormal fibula morphology
- abnormal gametogenesis
- abnormal glucose tolerance
- abnormal interleukin level
- abnormal interleukin-1 secretion
- abnormal intestinal epithelium morphology
- abnormal intestinal mucosa morphology
- abnormal large intestine crypts of Lieberkuhn morphology
- abnormal limb bone morphology
- abnormal locomotor activation
- abnormal long bone hypertrophic chondrocyte zone
- abnormal long bone metaphysis morphology
- abnormal macrophage chemotaxis
- abnormal macrophage physiology
- abnormal male reproductive system morphology
- abnormal mineral homeostasis
- abnormal myocardial fiber physiology
- abnormal nitric oxide homeostasis
- abnormal renin activity
- abnormal response to new environment
- abnormal response to vitamins
- abnormal skin development
- abnormal spermatogenesis
- abnormal startle reflex
- abnormal tibia morphology
- abnormal trabecular bone morphology
- abnormal tumor necrosis factor level
- abnormal urine homeostasis
- abnormal vitamin D level
- absent mature ovarian follicles
- alopecia
- asthenozoospermia
- cardiac fibrosis
- cardiac hypertrophy
- decreased body size
- decreased body weight
- decreased bone mineral density
- decreased circulating calcium level
- decreased circulating phosphate level
- decreased compact bone thickness
- decreased hair follicle cell proliferation
- decreased interleukin-6 secretion
- decreased intestinal calcium absorption
- decreased prepulse inhibition
- decreased regulatory T cell number
- decreased splenocyte proliferation
- decreased susceptibility to autoimmune diabetes
- decreased susceptibility to parasitic infection
- decreased systemic arterial systolic blood pressure
- decreased uterus weight
- decreased vertical activity
- dermal cysts
- dermatitis
- dilated hair follicles
- dilated seminiferous tubules
- disorganized long bone epiphyseal plate
- ear inflammation
- enlarged parathyroid gland
- epidermal cyst
- female infertility
- flat face
- hypertension
- hypoactivity
- impaired coordination
- increased activity of parathyroid
- increased bone mass
- increased bone mineral density
- increased circulating alkaline phosphatase level
- increased circulating angiotensinogen level
- increased circulating atrial natriuretic factor
- increased circulating follicle stimulating hormone level
- increased circulating luteinizing hormone level
- increased circulating parathyroid hormone level
- increased circulating renin level
- increased fluid intake
- increased heart weight
- increased left ventricle weight
- increased long bone epiphyseal plate size
- increased osteoblast cell number
- increased osteoid volume
- increased renin activity
- increased sensitivity to xenobiotic induced morbidity/mortality
- increased susceptibility to autoimmune diabetes
- increased susceptibility to induced colitis
- increased systemic arterial diastolic blood pressure
- increased systemic arterial systolic blood pressure
- increased testis weight
- increased thymus weight
- increased trabecular bone volume
- increased urine calcium level
- increased urine potassium level
- increased urine sodium level
- increased width of hypertrophic chondrocyte zone
- intestinal inflammation
- intestinal ulcer
- male infertility
- mixed cellular infiltration to dermis
- oligozoospermia
- polyuria
- postnatal growth retardation
- premature death
- reduced female fertility
- reduced male fertility
- rickets
- short femur
- short snout
- short stride length
- short tibia
- slow postnatal weight gain
- sparse vibrissae
- thymus hyperplasia
- uterus hypoplasia
- weight loss
role in cell
- recruitment
- expression in
- growth
- production in
- apoptosis
- phosphorylation in
- number
- differentiation
- migration
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- nuclear lipid microdomain
- Cytoplasm
- cell surface
- perinuclear region
- Plasma Membrane
- Mitochondria
- cytosol
- caveolae
- nuclear foci
- dense fibrillar component
- nucleoplasm
- nuclear matrix
- growth cone
- neurites
- transverse tubules
- filopodia
- cell membrane leading edge
- chromatin
- perikaryon
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vdr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal development
- negative regulation of cell proliferation
- mammary gland branching involved in pregnancy
- decidualization
- lactation
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of keratinocyte proliferation
- negative regulation of transcription from RNA polymerase II promoter
- intestinal absorption
- skeletal system development
- negative regulation of transcription, DNA-dependent
- vitamin D receptor signaling pathway
- calcium ion transport
- positive regulation of vitamin D receptor signaling pathway
- phosphate ion transmembrane transport
- positive regulation of bone mineralization
- mRNA transcription from RNA polymerase II promoter
- positive regulation of keratinocyte differentiation
- apoptotic process involved in mammary gland involution
- positive regulation of apoptotic process involved in mammary gland involution
- cell morphogenesis
- regulation of calcidiol 1-monooxygenase activity
- cellular calcium ion homeostasis
- positive regulation of gene expression
- cell differentiation
- positive regulation of vitamin D 24-hydroxylase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- receptor complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- zinc ion binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- vitamin D response element binding
- retinoid X receptor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity