Sumo1 Gene Summary [Mouse]
Predicted to enable enzyme binding activity; potassium channel regulator activity; and protein tag activity. Involved in several processes, including positive regulation of ATPase-coupled calcium transmembrane transporter activity; regulation of cardiac muscle cell contraction; and regulation of protein stability. Acts upstream of or within several processes, including PML body organization; protein localization to nuclear pore; and protein sumoylation. Located in XY body and nuclear body. Is active in glutamatergic synapse; postsynaptic cytosol; and presynaptic cytosol. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in orofacial cleft 10. Orthologous to human SUMO1 (small ubiquitin like modifier 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Sumo1 |
| Official Name | small ubiquitin-like modifier 1 [Source:MGI Symbol;Acc:MGI:1197010] |
| Ensembl ID | ENSMUSG00000026021 |
| Bio databases IDs | |
| Aliases | small ubiquitin-like modifier 1 |
| Synonyms | DAP1, GMP1, OFC10, PIC1, SENP2, SENTRIN, small ubiquitin-like modifier 1, SMT3, SMT3C, SMT3H3, SMTP3, UBL1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sumo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin family
- ubiquitin protein ligase binding
- diglycine motif
- protease binding
- Ubl1_cv_Nsp3_N-like
- potassium channel regulator
- Ubiquitin homologues
- enzyme binding
- transcription factor binding
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Sumo1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- rheumatoid arthritis
- hyperplasia
- heart disease
- heart failure
- orofacial cleft 10
- complete testicular feminization syndrome
- chronic obstructive pulmonary disease
- infection by Listeria monocytogenes
regulated by
- TP53
- streptozocin
- MYC
- arsenic trioxide
- tretinoin
- lipopolysaccharide
- fisetin
- D-glucose
- apigenin
- adenosine triphosphate
role in cell
- cell viability
- growth
- apoptosis
- expression in
- phosphorylation in
- cell death
- survival
- activation in
- proliferation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- glutaminergic synapse
- fibrillar center
- heterochromatin
- ribonucleoprotein granule
- Cytoplasm
- perinuclear region
- cellular membrane
- Plasma Membrane
- cytosol
- nuclear foci
- nuclear pores
- sister chromatids
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear rim
- sex chromatin
- nuclear envelope
- nuclear speckles
- DNA replication foci
- PML nuclear bodies
- mitotic spindle
- centromeres
- dendrites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sumo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- negative regulation of action potential
- protein localization to nuclear pore
- negative regulation of protein import into nucleus
- protein sumoylation
- regulation of protein localization
- regulation of cardiac muscle cell contraction
- palate development
- negative regulation of sequence-specific DNA binding transcription factor activity
- negative regulation of DNA binding
- cellular response to heat
- negative regulation of transcription, DNA-dependent
- cellular response to cadmium ion
- negative regulation of transcription by transcription factor localization
- protein stabilization
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- PML body organization
- positive regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- nuclear body
- PML body
- voltage-gated potassium channel complex
- nuclear speck
- nucleolus
- plasma membrane
- nucleoplasm
- nuclear pore
- XY body
- nucleus
- nuclear stress granule
- nuclear membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- ubiquitin protein ligase binding
- small protein activating enzyme binding
- transcription factor binding
- small conjugating protein ligase binding
- protein tag
- potassium channel regulator activity
- enzyme binding