FBXL3
FBXL3 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | FBXL3 |
| Official Name | F-box and leucine rich repeat protein 3 [Source:HGNC Symbol;Acc:HGNC:13599] |
| Ensembl ID | ENSG00000005812 |
| Bio databases IDs | |
| Aliases | F-box and leucine rich repeat protein 3 |
| Synonyms | FBK,FBL3,FBL3A,F-box and leucine-rich repeat protein 3,FBXL3A,IDDSFAS,Ovtm,Play68 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- leucine-rich repeat
- F-box domain superfamily
- ubiquitin-protein transferase activity
- F-box-like
- enzyme
- protein binding
- Leucine-rich repeat domain of FBXL3 and related proteins
Pathways
Biological processes and signaling networks where the FBXL3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- HSP90AB1
- TLK2
- RFX1
- CRY2
- CRY1
- PPP2R5D
- SKP1
- HSP90AA1
- C9orf72
- NHERF1
disease
- mental retardation, short stature, facial anomalies, and joint dislocations
regulated by
regulates
- proteasome
- cryptochrome
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the FBXL3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- protein destabilization
- rhythmic process
- entrainment of circadian clock by photoperiod
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- regulation of circadian rhythm
- protein ubiquitination
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- nuclear body
- ubiquitin ligase complex
- cytosol
- SCF ubiquitin ligase complex
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding