TLK2 Gene Summary [Human]
This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Details
| Type | Protein Coding |
| Official Symbol | TLK2 |
| Official Name | tousled like kinase 2 [Source:HGNC Symbol;Acc:HGNC:11842] |
| Ensembl ID | ENSG00000146872 |
| Bio databases IDs | |
| Aliases | tousled like kinase 2 |
| Synonyms | 4933403M19RIK, HsHPK, MRD57, PKU-ALPHA, PKU-α, Tlk, Tlk2 predicted, tousled-like kinase 2, tousled-like kinase 2 (Arabidopsis) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TLK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
- identical protein binding
Pathways
Biological processes and signaling networks where the TLK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant mental retardation type 57
- mental retardation
- hereditary disorder
- non-insulin-dependent diabetes mellitus
- developmental disorder
- neurodevelopmental disorder
- medulloblastoma
- brain cancer
role in cell
- number
- organization
- response by
- signal transduction in
- replication in
- DNA damage response
- segregation
- localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TLK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to gamma radiation
- negative regulation of autophagy
- chromosome segregation
- protein phosphorylation
- chromatin organization
- response to DNA damage stimulus
- peptidyl-serine phosphorylation
- nucleus localization
- intracellular signal transduction
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- intermediate filament
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- protein serine/threonine kinase activity