Fbxl3 Gene Summary [Mouse]
Contributes to ubiquitin-protein transferase activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; entrainment of circadian clock by photoperiod; and protein destabilization. Located in cytosol and nucleus. Is expressed in embryo; extraembryonic component; inner cell mass; and trophectoderm. Orthologous to human FBXL3 (F-box and leucine rich repeat protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxl3 |
| Official Name | F-box and leucine-rich repeat protein 3 [Source:MGI Symbol;Acc:MGI:1354702] |
| Ensembl ID | ENSMUSG00000022124 |
| Bio databases IDs | |
| Aliases | F-box and leucine-rich repeat protein 3 |
| Synonyms | FBK, FBL3, FBL3A, F-box and leucine-rich repeat protein 3, FBXL3A, IDDSFAS, Ovtm, Play68 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- leucine-rich repeat
- F-box domain superfamily
- ubiquitin-protein transferase activity
- F-box-like
- enzyme
- protein binding
- Leucine-rich repeat domain of FBXL3 and related proteins
Pathways
Biological processes and signaling networks where the Fbxl3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein destabilization
- rhythmic process
- entrainment of circadian clock by photoperiod
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- regulation of circadian rhythm
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- ubiquitin ligase complex
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding