DLEC1 Gene Summary [Human]
The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016]
Details
| Type | Retained Intron |
| Official Symbol | DLEC1 |
| Official Name | DLEC1 cilia and flagella associated protein [Source:HGNC Symbol;Acc:HGNC:2899] |
| Ensembl ID | ENSG00000008226 |
| Bio databases IDs | |
| Aliases | DLEC1 cilia and flagella associated protein, cilia and flagella associated protein 81 |
| Synonyms | CFAP81, D630005C06RIK, deleted in lung and esophageal cancer 1, deleted in lung and oesophageal cancer 1, DLC-1, DLEC1 cilia and flagella associated protein, F56, FAP81 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DLEC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- alpha-tubulin binding
- Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DLEC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to tumor cell
- negative regulation of cell proliferation
- spermatogenesis
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cilium
- cytosol
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein binding
- beta-tubulin binding
- alpha-tubulin binding