Dlec1 Gene Summary [Mouse]
Predicted to enable alpha-tubulin binding activity and beta-tubulin binding activity. Involved in spermatogenesis. Predicted to be located in cytosol. Is expressed in brain and testis. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human DLEC1 (DLEC1 cilia and flagella associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Dlec1 |
| Official Name | deleted in lung and esophageal cancer 1 [Source:MGI Symbol;Acc:MGI:2443671] |
| Ensembl ID | ENSMUSG00000038060 |
| Bio databases IDs | |
| Aliases | deleted in lung and esophageal cancer 1 |
| Synonyms | CFAP81, D630005C06RIK, deleted in lung and esophageal cancer 1, deleted in lung and oesophageal cancer 1, DLC-1, DLEC1 cilia and flagella associated protein, F56, FAP81 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dlec1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- alpha-tubulin binding
- Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dlec1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to tumor cell
- negative regulation of cell proliferation
- spermatogenesis
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cilium
- cytosol
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein binding
- beta-tubulin binding
- alpha-tubulin binding