EIF4B Gene Summary [Human]
Enables RNA binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Located in cytosol. Biomarker of autism spectrum disorder and major depressive disorder. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | EIF4B |
| Official Name | eukaryotic translation initiation factor 4B [Source:HGNC Symbol;Acc:HGNC:3285] |
| Ensembl ID | ENSG00000063046 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 4B |
| Synonyms | 2310046H11RIK, Eif4a2, elF4B, eukaryotic translation initiation factor 4B, IF4B, Initiation Factor M3, PRO1843 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EIF4B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- aspartic acid arginine tyrosine and glycine rich domain
- translation initiation factor
- protein binding
- basic domain
- translation regulator
- RNA binding
Pathways
Biological processes and signaling networks where the EIF4B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- breast cancer
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- epithelial cancer
- aortic valve calcification
- pneumonitis
- Parkinson disease
- breast carcinoma
role in cell
- growth
- expression in
- activation
- apoptosis
- number
- cell death
- cellular infiltration by
- binding
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- synaptic vesicles
- perikaryon
- dendrites
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EIF4B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- translational initiation
- regulation of translational initiation
Cellular Component
Where in the cell the gene product is active
- eukaryotic translation initiation factor 4F complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- protein binding
- RNA binding