SS18L2 Gene Summary [Human]
Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused in-frame to the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or SSX4 (MIM 300326) gene. The SS18L2 gene is homologous to SS18.[supplied by OMIM, Jul 2002]
Details
| Type | Protein Coding |
| Official Symbol | SS18L2 |
| Official Name | SS18 like 2 [Source:HGNC Symbol;Acc:HGNC:15593] |
| Ensembl ID | ENSG00000008324 |
| Bio databases IDs | |
| Aliases | SS18 like 2, SYT homolog 2 |
| Synonyms | 1110020I04Rik, Deb1, KIAA-iso, SS18 like 2, SS18, nBAF chromatin remodeling complex subunit like 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SS18L2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SSXT protein (N-terminal region)
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SS18L2 gene, providing context for its role in the cell.
Molecular Function
What the gene product does at the molecular level
- protein binding