HAUS8 Gene Summary [Human]
HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
Details
| Type | Protein Coding |
| Official Symbol | HAUS8 |
| Official Name | HAUS augmin like complex subunit 8 [Source:HGNC Symbol;Acc:HGNC:30532] |
| Ensembl ID | ENSG00000131351 |
| Bio databases IDs | |
| Aliases | HAUS augmin like complex subunit 8 |
| Synonyms | 2410004L22Rik, 4HAUS augmin-like complex, subunit 8, DGT4, HAUS augmin like complex subunit 8, HAUS augmin-like complex, subunit 8, HICE1, NY-SAR-48, RGD1311565 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HAUS8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- asthma
role in cell
- cell death
- formation
- cycling
- formation in
- interaction in
- misalignment in
- nucleation in
- interaction
- misalignment
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
- spindle fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HAUS8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- spindle assembly
- centrosome cycle
- regulation of microtubule nucleation
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- spindle pole
- nuclear microtubule
- cytosol
- HAUS complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule binding