ZFP36 Gene Summary [Human]
Enables several functions, including 14-3-3 protein binding activity; heat shock protein binding activity; and mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to growth factor stimulus; and regulation of gene expression. Acts upstream of or within mRNA catabolic process. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleus. Part of ribonucleoprotein complex. Colocalizes with RISC-loading complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZFP36 |
| Official Name | ZFP36 ring finger protein [Source:HGNC Symbol;Acc:HGNC:12862] |
| Ensembl ID | ENSG00000128016 |
| Bio databases IDs | |
| Aliases | ZFP36 ring finger protein, tristetraprolin |
| Synonyms | G0S24, GOS24, GROWTH FACTOR INDUCIBLE NUCLEAR protein 475, NUP475, RNF162A, TIS11, TIS11D, TISII, TRISTETRAPROLIN, TRISTETRAPROLINE, TTP, ZFP36 ring finger protein, zinc finger protein 36, ZINC FINGER TRANSCRIPTIONAL REGULATOR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZFP36 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein kinase binding
- mRNA binding
- RNA recognition motif
- heat shock protein binding
- protein binding activity, bridging
- enzyme binding
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
- phosphorylation site
- zinc finger
- mRNA 3' UTR binding
- binding protein
- C-C chemokine binding
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- breast cancer
- neoplasia
- hepatocellular carcinoma
- metastasis
- non-small cell lung cancer
- cervical cancer
- diabetic nephropathy
- epithelial cancer
- lung cancer
role in cell
- expression in
- production in
- cell death
- proliferation
- phosphorylation in
- survival
- apoptosis
- activation
- number
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytoplasmic mRNA processing body
- Cytoplasm
- cytoplasmic aggregates
- cytosol
- stress granule
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZFP36 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 3'-UTR-mediated mRNA destabilization
- nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- response to starvation
- response to wounding
- positive regulation of fat cell differentiation
- regulation of mRNA stability
- negative regulation of erythrocyte differentiation
- mRNA catabolic process
- negative regulation of transcription from RNA polymerase II promoter
- MAPK cascade
- negative regulation of interleukin-2 production
- regulation of keratinocyte proliferation
- positive regulation of gene silencing by miRNA
- cellular response to tumor necrosis factor
- mRNA transport
- 3'-UTR-mediated mRNA stabilization
- regulation of keratinocyte differentiation
- negative regulation of translation involved in gene silencing by miRNA
- p38MAPK cascade
- negative regulation of inflammatory response
- regulation of tumor necrosis factor production
- cellular response to fibroblast growth factor stimulus
- hemopoietic stem cell differentiation
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
- nuclear-transcribed mRNA poly(A) tail shortening
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- cellular response to granulocyte macrophage colony-stimulating factor stimulus
- cellular response to lipopolysaccharide
- cellular response to glucocorticoid stimulus
- cellular response to epidermal growth factor stimulus
- myeloid cell differentiation
- negative regulation of viral transcription
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- cytoplasm
- cytosol
- cytoplasmic mRNA processing body
- CCR4-NOT complex
- exosome (RNase complex)
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- protein kinase binding
- heat shock protein binding
- RNA polymerase binding
- DNA binding
- RNA binding
- protein binding
- mRNA 3'-UTR AU-rich region binding
- metal ion binding
- mRNA binding
- 14-3-3 protein binding
- enzyme binding