SLC16A10 Gene Summary [Human]
SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]
Details
| Type | Protein Coding |
| Official Symbol | SLC16A10 |
| Official Name | solute carrier family 16 member 10 [Source:HGNC Symbol;Acc:HGNC:17027] |
| Ensembl ID | ENSG00000112394 |
| Bio databases IDs | |
| Aliases | solute carrier family 16 member 10 |
| Synonyms | 2610103N14RIK, 9830169E08, MCT10, PRO0813, solute carrier family 16 member 10, solute carrier family 16 (monocarboxylic acid transporters), member 10, TAT1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC16A10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tyrosine transporter
- phenylalanine transporter
- tryptophan transporter
- Major Facilitator Superfamily
- protein binding
- aromatic amino acid transporter
- thyroid hormone transporter
- monocarboxylate transporter 1
- amino acid transporter
- transporter
Pathways
Biological processes and signaling networks where the SLC16A10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriatic arthritis
- atypical femur fracture
- preeclampsia
- dental caries
regulates
- ligands of SLC16A10
- L-tryptophan
- L-triiodothyronine
- aromatic amino acid
- 4-hydroxy-3-methoxyphenylalanine
- levothyroxine
- N-acetyl-L-tyrosine
- bicarbonate
- N-acetyltryptophan
- thyroid hormone
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- intracellular membrane-bounded organelle
- Cytoplasm
- cell periphery
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC16A10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- thyroid-stimulating hormone secretion
- thyroid hormone generation
- monocarboxylic acid transport
- tyrosine transport
- tryptophan transport
- aromatic amino acid transport
- phenylalanine transport
- amino acid transport
- amino acid transmembrane transport
- thyroid hormone transport
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cell junction
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- L-tryptophan transmembrane transporter activity
- aromatic amino acid transmembrane transporter activity
- amino acid transmembrane transporter activity
- L-phenylalanine transmembrane transporter activity
- thyroid hormone transmembrane transporter activity
- monocarboxylic acid transmembrane transporter activity
- L-tyrosine transmembrane transporter activity