STAU2 Gene Summary [Human]
Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Details
| Type | Protein Coding |
| Official Symbol | STAU2 |
| Official Name | staufen double-stranded RNA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:11371] |
| Ensembl ID | ENSG00000040341 |
| Bio databases IDs | |
| Aliases | staufen double-stranded RNA binding protein 2 |
| Synonyms | 39K2, 39K3, staufen double-stranded RNA binding protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STAU2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hsp70 protein binding
- protein kinase binding
- Double-stranded RNA binding motif
- double-stranded RNA binding motif (DSRM) superfamily
- double-stranded RNA binding
- ribosome binding
- protein binding
- Staufen C-terminal domain
- kinesin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- malaria
- non-insulin-dependent diabetes mellitus
- pelvic organ prolapse
- inguinal hernia
- hepatitis B
- ductal breast carcinoma
- ductal breast cancer
- male pattern hair loss
regulates
role in cell
- number
- development
- assembly
- organization
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- polyribosome fractions
- glutaminergic synapse
- postsynaptic region
- ribosome
- Nucleus
- nucleoli
- nuclear envelope
- stress granule
- perikaryon
- axons
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STAU2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- regulation of filopodium assembly
- positive regulation of dendritic spine morphogenesis
- eye morphogenesis
- regulation of actin cytoskeleton organization
- intracellular mRNA localization
- positive regulation of long term synaptic depression
- cellular response to oxidative stress
- protein localization to synapse
- positive regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- endoplasmic reticulum
- neuronal cell body
- nucleolus
- neuron projection
- plasma membrane
- microtubule
- nuclear membrane
- dendritic shaft
- membrane
- dendrite cytoplasm
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- double-stranded RNA binding
- ribosome binding
- kinesin binding
- mRNA binding
- mitogen-activated protein kinase binding
- Hsp70 protein binding