Stau2 Gene Summary [Mouse]
Predicted to enable several functions, including Hsp70 protein binding activity; RNA binding activity; and kinesin binding activity. Predicted to be involved in several processes, including anterograde dendritic transport of messenger ribonucleoprotein complex; positive regulation of long-term synaptic depression; and positive regulation of nervous system development. Predicted to be located in axon; dendritic shaft; and nuclear membrane. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including cytoplasmic stress granule; neuron projection; and neuronal cell body. Is expressed in several structures, including central nervous system; olfactory epithelium; retina; submandibular gland primordium; and tooth. Orthologous to human STAU2 (staufen double-stranded RNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stau2 |
| Official Name | staufen double-stranded RNA binding protein 2 [Source:MGI Symbol;Acc:MGI:1352508] |
| Ensembl ID | ENSMUSG00000025920 |
| Bio databases IDs | |
| Aliases | staufen double-stranded RNA binding protein 2 |
| Synonyms | 39K2, 39K3, staufen double-stranded RNA binding protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stau2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hsp70 protein binding
- protein kinase binding
- Double-stranded RNA binding motif
- double-stranded RNA binding motif (DSRM) superfamily
- double-stranded RNA binding
- ribosome binding
- protein binding
- Staufen C-terminal domain
- kinesin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- malaria
- non-insulin-dependent diabetes mellitus
- pelvic organ prolapse
- inguinal hernia
- hepatitis B
- ductal breast carcinoma
- ductal breast cancer
- male pattern hair loss
regulates
role in cell
- number
- development
- assembly
- organization
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- polyribosome fractions
- glutaminergic synapse
- postsynaptic region
- ribosome
- Nucleus
- nucleoli
- nuclear envelope
- stress granule
- perikaryon
- axons
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stau2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- regulation of filopodium assembly
- positive regulation of dendritic spine morphogenesis
- eye morphogenesis
- regulation of actin cytoskeleton organization
- intracellular mRNA localization
- positive regulation of long term synaptic depression
- cellular response to oxidative stress
- protein localization to synapse
- positive regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- endoplasmic reticulum
- neuronal cell body
- nucleolus
- neuron projection
- plasma membrane
- microtubule
- nuclear membrane
- dendritic shaft
- membrane
- dendrite cytoplasm
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- double-stranded RNA binding
- ribosome binding
- kinesin binding
- mRNA binding
- mitogen-activated protein kinase binding
- Hsp70 protein binding