PRKAR1B Gene Summary [Human]
The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | PRKAR1B |
| Official Name | protein kinase cAMP-dependent type I regulatory subunit beta [Source:HGNC Symbol;Acc:HGNC:9390] |
| Ensembl ID | ENSG00000188191 |
| Bio databases IDs | |
| Aliases | protein kinase cAMP-dependent type I regulatory subunit beta |
| Synonyms | LOC645590, MASNS, PKA RI beta, PKA RI β, PRKAR1, protein kinase, cAMP dependent regulatory, type I beta, protein kinase, cAMP dependent regulatory, type I β, protein kinase cAMP-dependent type I regulatory subunit beta, protein kinase cAMP-dependent type I regulatory subunit β, RGD1563094, RIbeta |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRKAR1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Cyclic nucleotide-binding domain
- protein kinase
- protein kinase A binding
- protein kinase binding
- cAMP-dependent protein kinase inhibitor activity
- 3',5'-cAMP binding
- protein binding
- DD_R_PKA_DPY30-like
- cAMP-dependent protein kinase regulator
- Cyclic nucleotide-monophosphate binding domain
- CAP_ED
Pathways
Biological processes and signaling networks where the PRKAR1B gene in human plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Apelin Adipocyte Signaling Pathway
- Apelin Pancreas Signaling Pathway
- BMP signaling pathway
- Calcium Signaling
- CDK5 Signaling
- Corticotropin Releasing Hormone Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Endocannabinoid Developing Neuron Pathway
- eNOS Signaling
- Ephrin A Signaling
- Gαs Signaling
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- Myc Mediated Apoptosis Signaling
- Netrin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- Phototransduction Pathway
- PXR/RXR Activation
- Relaxin Signaling
- Renin-Angiotensin Signaling
- Sonic Hedgehog Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Marbach-Schaaf neurodevelopmental syndrome
- primary ciliary dyskinesia
- Crohn disease
- primary ciliary dyskinesia type 18
- idiopathic pulmonary fibrosis
- fracture of bone
- autosomal recessive polycystic kidney disease
- touch abnormality
- endometriosis
role in cell
- quantity
- pyroptosis
- long term synaptic depression
- autophagy in
- long-term potentiation
- extravasation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- cytosol
- neurites
- synapse
- multivesicular bodies
- perikaryon
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRKAR1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cAMP-dependent protein kinase activity
- positive regulation of long-term synaptic potentiation
- regulation of protein phosphorylation
- positive regulation of excitatory postsynaptic membrane potential
- protein phosphorylation
- learning or memory
Cellular Component
Where in the cell the gene product is active
- cytosol
- multivesicular body
- cAMP-dependent protein kinase complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein kinase A catalytic subunit binding
- cAMP binding
- cAMP-dependent protein kinase regulator activity
- cAMP-dependent protein kinase inhibitor activity