TARBP2 Gene Summary [Human]
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | TARBP2 |
| Official Name | TARBP2 subunit of RISC loading complex [Source:HGNC Symbol;Acc:HGNC:11569] |
| Ensembl ID | ENSG00000139546 |
| Bio databases IDs | |
| Aliases | TARBP2 subunit of RISC loading complex |
| Synonyms | LOQS, Prbp, TARBP2, RISC loading complex RNA binding subunit, TARBP2 subunit of RISC loading complex, TRBP, TRBP1, TRBP2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TARBP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Double-stranded RNA binding motif
- double-stranded RNA binding motif (DSRM) superfamily
- double-stranded RNA binding
- enzyme binding
- protein homodimerization
- protein binding
- dsRNA-binding domain
- identical protein binding
- RNA binding
Pathways
Biological processes and signaling networks where the TARBP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- Burkitt lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- cardiomyopathy
- oligozoospermia
- systolic dysfunction
role in cell
- expression in
- proliferation
- differentiation
- processing in
- transformation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TARBP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
- pre-miRNA processing
- production of miRNAs involved in gene silencing by miRNA
- negative regulation of protein kinase activity
- regulation of translation
- regulation of viral transcription
- negative regulation of defense response to virus by host
- positive regulation of viral genome replication
- small RNA loading onto RISC
- production of siRNA involved in RNA interference
- regulation of production of small RNA involved in gene silencing by RNA
- regulation of production of siRNA involved in chromatin silencing by small RNA
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- nuclear body
- cytoplasm
- cytosol
- RISC-loading complex
- RNA-induced silencing complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- pre-mRNA binding
- identical protein binding
- protein homodimerization activity
- protein binding
- double-stranded RNA binding
- siRNA binding
- pre-miRNA binding
- enzyme binding