LARP7 Gene Summary [Human]

This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Details

Type
Nonsense Mediated Decay
Official Symbol
LARP7
Official Name
La ribonucleoprotein 7, transcriptional regulator [Source:HGNC Symbol;Acc:HGNC:24912]
Ensembl ID
ENSG00000174720
Bio databases IDs NCBI: 51574 Ensembl: ENSG00000174720
Aliases La ribonucleoprotein 7, transcriptional regulator, P-TEFb-interaction protein for 7SK stability
Synonyms ALAZS, C330027G06RIK, D3Wsu161e, DKFZp564K112, HDCMA18P, hLARP7, La ribonucleoprotein 7, transcriptional regulator, PIP7S
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LARP7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • snRNA binding
  • RNA recognition motif (RRM) superfamily
  • La domain
  • RNA recognition motif
  • U6 snRNA binding
  • protein binding
  • RNA binding motif
  • LA motif RNA-binding domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • Alazami syndrome
  • gastric carcinoma
  • gastric epithelial cancer
  • mental retardation
regulated by
regulates
role in cell
  • binding
  • synthesis in
  • number
  • proliferation
  • binding in
  • acetylation in
  • senescence

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • cytosol
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human LARP7 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of transcription from RNA polymerase II promoter
  • box C/D snoRNA 3'-end processing
  • RNA splicing
  • negative regulation of transcription elongation from RNA polymerase II promoter
  • spermatogenesis
  • regulation of nuclear mRNA splicing, via spliceosome
  • cell differentiation
  • mRNA processing
  • negative regulation of viral transcription

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytosol
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • U6 snRNA binding
  • RNA binding
  • protein binding
  • mRNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.